Aug 19, 2026 · 44 min · 14 segments
Kiran Krishnan, the Founder of Microbiome Labs, joins me again today for Part 2 of the two-part series on how a healthy microbiome impacts longevity. In Part 1, Kiran provides in-depth examples of…
So is there any sort of case for back to that 50 billion strain probiotic you mentioned? Do you feel like there is a case for that? maybe short course of a high burst of probiotics to kind of, I don't know, re-inoculate the gut after heavy antibiotic use, and then to maybe go back to a maintenance of like the Megaspore?
And in fact, there's two big published studies that show that those kind of high concentration probiotics actually negate the recovery of your microbiome.
Which is completely opposite, right? But what's interesting about it is one of the things we came out saying in 2013 when we first started talking about the microbiome is that there is an issue with these high-dose, high-concentration probiotics that just have lots of different strains in it competing with your natural flora.
Because if you take a lactobacillus acidophilus, for example, and you naturally have acidophilus in your gut, this acidophilus could very well compete for the binding sites with your natural acidophilus or negate it in some way.
We always got the question about what do we do to recover the gut from antibiotics? Do we take a broad spectrum probiotic? Our answer has always been, no, I would hypothesize that it would actually negate the repair.
And then sure enough, there was two big studies that came out in 2018 and I think 2019 that showed exactly that, that after a course of antibiotics, if you took these kind of high concentration, multi-strain probiotics, it slowed down the recovery of your microbiome.
In contrast, we did it and we published a study on the spores showing that when you took the spores, not only with the antibiotic, but right after the coarse antibiotic, it actually improved and accelerated the recovery.
I think it's important to understand what's happening in the microbiome when you take antibiotics.
So let's say you have all my, each of my fingers are different microbes in the gut microbiome, right? And they're all at kind of equal level right now.
What happens when the antibody comes in within the first two and a half hours is all of them get knocked down by over 90%, all of the microbes equally.
So is there any sort of case for back to that 50 billion strain probiotic you mentioned? Do you feel like there is a case for that? maybe short course of a high burst of probiotics to kind of, I don't know, re-inoculate the gut after heavy antibiotic use, and then to maybe go back to a maintenance of like the Megaspore?
And in fact, there's two big published studies that show that those kind of high concentration probiotics actually negate the recovery of your microbiome.
Which is completely opposite, right? But what's interesting about it is one of the things we came out saying in 2013 when we first started talking about the microbiome is that there is an issue with these high-dose, high-concentration probiotics that just have lots of different strains in it competing with your natural flora.
Because if you take a lactobacillus acidophilus, for example, and you naturally have acidophilus in your gut, this acidophilus could very well compete for the binding sites with your natural acidophilus or negate it in some way.
We always got the question about what do we do to recover the gut from antibiotics? Do we take a broad spectrum probiotic? Our answer has always been, no, I would hypothesize that it would actually negate the repair.
And then sure enough, there was two big studies that came out in 2018 and I think 2019 that showed exactly that, that after a course of antibiotics, if you took these kind of high concentration, multi-strain probiotics, it slowed down the recovery of your microbiome.
In contrast, we did it and we published a study on the spores showing that when you took the spores, not only with the antibiotic, but right after the coarse antibiotic, it actually improved and accelerated the recovery.
I think it's important to understand what's happening in the microbiome when you take antibiotics.
So let's say you have all my, each of my fingers are different microbes in the gut microbiome, right? And they're all at kind of equal level right now.
What happens when the antibody comes in within the first two and a half hours is all of them get knocked down by over 90%, all of the microbes equally.
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