Immunoglobulin M
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Search complete. 99 mentions across 30 episodes found for "Immunoglobulin M".
Sep 19, 2026
Ben CourchiaHOST
Cohort 1 is the ABO incompatible cohort and was defined as a group O mother with a group A or a group B infant.
Ben CourchiaHOST
Now, for non-Group O maternal-infant mismatch, such as Group A mother with Group B infants, they were not classified as having an ABO incompatibility in the study because, as we know, the antibodies made by Group A and Group B people are of the IgM type and do not cross the placenta, in contrast to Group O individuals who make IgGs, and that does cross the placenta.
Ben CourchiaHOST
The second cohort, the ABO compatible, but RH incompatible cohort, was defined basically as an RH negative mother with a baby that was RH positive who were ABO compatible.
Ben CourchiaHOST
And there's a full flow of the patient in figure one, figure one.
Klaus LeyGUEST
So in the beginning, I think the thing starts with the CD4 T cells, but we haven't proven that yet.
Klaus LeyGUEST
Now, you probably know that epidemiologically, IgM antibodies to various self-antigens, including oxidized LDL, have a negative correlation with disease.
Klaus LeyGUEST
So think of the IgM antibody as the first respondent, a more primitive B cell that does not make a high-affinity antibody, and is B4.
Klaus LeyGUEST
of the CD4 T cells wake up and induce the isotype switch.
Klaus LeyGUEST
So the CD4 T cell help is needed to make IgGs, and other IgGs are the ones that are relevant here.
Klaus LeyGUEST
And IgGs are generally positively correlated with disease epidemiologically.
Klaus LeyGUEST
IgM good, IgG bad.
Klaus LeyGUEST
Well, you can only get an IgG if you have CD4 T-cell help.
Carrie HydeGUEST
We would, we would use that if we were doing like a DNA test, you can do that with a DNA test.
Carrie HydeGUEST
But if you're doing, if you're checking for IgA and IgM, like we are, we actually
JayHOST
have
Carrie HydeGUEST
to have 0.5, which is a very small amount of saliva.
Carrie HydeGUEST
And we put that on the list.
Carrie HydeGUEST
When you get the list back, it'll tell you how, if it's strong, if it's weak, if it's absolutely avoid at all costs.
Carrie HydeGUEST
And that is based on how many of those IgA or IgM antibodies came out, right? Like this is a full-blown war or this is kind of, I'm not really sure if you're a friend or a foe.
Carrie HydeGUEST
And so based on that would depend on how severe your reaction would be.
Joseph BurrascanoGUEST
... you know, there's a paradox here.
Joseph BurrascanoGUEST
We're taught in medical school that with an infection, your first response is an IgM response.
Joseph BurrascanoGUEST
You get a positive IgM antibody response.
Ira PastorHOST
Yep.
Joseph BurrascanoGUEST
It starts within a few days, peaks in a couple of weeks, three weeks, and is usually handed over after about 30 days to an IgG response.
Joseph BurrascanoGUEST
So you think about it, well, if you s- do a test on someone with an infection, you expect if you see an IgM, it's a recent infection.
Joseph BurrascanoGUEST
If you see an IgG and no IgM, it's a late infection.
Joseph BurrascanoGUEST
Pretty clear-cut.
Chris MoldaGUEST
So, so I, like I said, I've had a lot of Lyme patients, and so I finally had, um, somebody retest for me, because you ha- you can't re- So when somebody does a Lyme test, you're, you're looking at, like, either you're looking at the DNA or you're looking at the RNA of the bacteria.
Chris MoldaGUEST
So you're looking, do I see the bacteria in the blood? But then a lot of these Lyme tests will look at the antibodies, like IgM or IgG, and what that's looking at is that's looking at your body's reaction to it.
Chris MoldaGUEST
And for people who don't know, IgM antibodies are the first antibodies that come out.
Chris MoldaGUEST
So think chickenpox.
Chris MoldaGUEST
When you get chickenpox, your body releases all of these Ig- IgM antibodies to, to, to, to kill off and to deal with the chickenpox that you got.
Chris MoldaGUEST
Then eventually chickenpox goes away and IgM goes away, but they send all of their information to your long-term immunity, which is called IgG.
Chris MoldaGUEST
And those antibodies last a long time, and if, you know, if you don't get exposed to chickenpox again, then they just go away, and when you're older you get shingles, which is a huge pain in the butt.
Chris MoldaGUEST
Which is why it'd be great if kids just got chickenpox, 'cause then we wouldn't have to deal with shingles, but that's a different story.
Shirley D'SaHOST
It's got the plasma cells.
Shirley D'SaHOST
It's got the IgM.
Shirley D'SaHOST
It's ...
Shirley D'SaHOST
And these IgMs are not just passive proteins.
Shirley D'SaHOST
You know, some of them are kind of roam around doing things of an im- immunological nature, and that gives you a whole set of other what are called monoclonal gammopathies of clinical significance.
Shirley D'SaHOST
And this is a, a, a very big topic for us as doctors who deal with these conditions.
Shirley D'SaHOST
Monoclonal means of one type, uh, which is the IgM paraprotein or M protein, and gammopathies is when you have the gamma globulins, which are The group of proteins in which all the immunoglobulins sit.
Shirley D'SaHOST
There's a whole group of those conditions which actually happen as we get older.
NickHOST
If we remember back to Immunology 101, once you have matched a B cell with its antigen, you need to help it do two things.
NickHOST
One is to fine-tune the antibody receptor by doing something called somatic hypermutation, and the other is to change the standard old IgM and maybe a bit of IgD to your other antibody isotypes, IgG, A, and E.
NickHOST
Remember that these are the active heavy chain components of the immune system.
NickHOST
And you don't get them for free.
KaleHOST
But look, regardless, our naive B cell is no longer as naive as it has been in the past.
KaleHOST
And what it will do now is start to divide.
KaleHOST
And a proportion of these cells will start to produce an early IgM antibody.
KaleHOST
Remember that the B-cell receptor is just its immunoglobulin lodged in its surface in the form of either an IgM or actually also an IgD molecule.
Dean MitchellHOST
So let's get into a little bit about, you know, essentially there's like sort of two levels of testing.
Dean MitchellHOST
There's the ELISA testing, which is the antibodies, you know, the immediate IgM and IgG.
Dean MitchellHOST
And then there's what's called Western blot, which checks for specific proteins to the Lyme bacteria.
Dean MitchellHOST
But here's where the issue comes in.
7 MINS LATER
Richard HorowitzGUEST
It doesn't mean you have Lyme.
Dean MitchellHOST
Okay.
Richard HorowitzGUEST
But what you were describing with the IgM-CDC-IgM block, where you need two out of those three bands, 2341 is one of those ones.
Richard HorowitzGUEST
The 41 bands is actually considered positive for an early IgM, but here's the kicker.
Sarina ElmariahGUEST
Right.
Sarina ElmariahGUEST
So the type two autoimmune is mediated by an IgG or actually even an IgM autoantibody to the high affinity IgE receptor or to IgE itself.
Sarina ElmariahGUEST
OK, so that's the testing where you can actually look for that autoantibody on those autologous serum skin tests.
Sarina ElmariahGUEST
You may see it as ASST.
Thomas CowanGUEST
which means there wasn't even anything in the mucus of somebody with measles who broke down, who made the cells die.
Michael KarlfeldtHOST
And so when people look like, you know, you do the titers like Epstein-Barr virus, IgG, IgM, IgA, all of that, what is that?
Thomas CowanGUEST
So here's a paper that has a quote from the world's leading expert on antibodies.
Thomas CowanGUEST
So you're talking about, okay, so they find these antibodies, allegedly, and if you have an antibody, they say that it's specific against that virus or the, you know, Lyme bacteria, spirochete or whatever, right? That's the claim.
18 MINS LATER
Thomas CowanGUEST
In the antibody test, we just talked about our nonspecific and don't prove there's a spirochete and don't prove that there's anything happening in this person.
Michael KarlfeldtHOST
Complete house of cards.
Michael KarlfeldtHOST
So if you have, like other studies showing you have like 40 early line patients with the symptoms and then they see that 90% of them develop like the IgM antibodies.
Michael KarlfeldtHOST
So you're arguing that the antibodies test in itself, the 90% is faulty then.
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