303: The Molecule That's More Important Than Oxygen And How To Get More Of It - with Dr. Nathan S. Bryan

In this episode of *ReversABLE*, Josh Dech welcomes back Dr. Nathan S. Bryan, a researcher who has spent 25 years studying nitric oxide and its role in human physiology. Together, they explore how nitric oxide supports vascular function, oxygen delivery, inflammation regulation, and the body's natural repair processes—and why its relationship with chronic illness deserves closer scientific attention. The conversation begins with an unexpected topic: your mouth. Dr. Bryan discusses the relationship between the oral microbiome, certain mouthwash ingredients, and the body's ability to produce nitric oxide. They examine how oral bacteria participate in the nitrate–nitrite–nitric oxide pathway and why disrupting this process may have implications beyond dental health. Josh and Nathan then connect nitric oxide to broader questions in functional medicine and root-cause healing. They discuss inflammation, oxidative stress, immune dysfunction, microcirculation, environmental exposures, and the physiological processes involved in delivering oxygen and nutrients to tissues. For listeners navigating chronic gut symptoms or inflammatory conditions, this offers a wider perspective on the systems that interact with the immune system and overall health. The episode also explores the proposed vascular and metabolic components of Alzheimer's disease, nitric oxide research in stroke recovery, and the potential relationship between nitric oxide signaling and immune-cell behavior. Nathan explains his approach to restorative physiology and why he believes research should focus on the biological mechanisms contributing to disease, rather than only its downstream manifestations. The conversation becomes more controversial as Josh and Nathan question conventional pharmaceutical incentives, discuss the challenges of funding disruptive research, and share strong opinions about mainstream medical practice and the COVID-19 response. These perspectives are part of the discussion, not proof that the claims made are established scientific consensus. Finally, Nathan discusses nitric oxide products, the importance of understanding dose and safety, and practical habits he recommends considering, including exercise, nasal breathing, sunlight exposure, and reviewing oral-care choices. ### TOPICS DISCUSSED: - Nitric Oxide Biology And Its Role In Human Physiology - Chronic Inflammation, Oxidative Stress, And Root-Cause Mechanisms - Alzheimer's Disease, Vascular Health, And Cognitive Function - Oxygen Delivery, Blood Flow, And Hyperbaric Oxygen Therapy - Pharmaceutical Incentives And The Debate Over Symptom Management Versus Root-Cause Treatment - Nitric Oxide Dosing, Supplement Products, And Safety Considerations - Autoimmunity, Macrophage Signaling, And Immune Dysfunction - Environmental Toxicity, Detoxification, And The Body's Natural Repair Processes - The Oral Microbiome, Mouthwash, Fluoride, And Nitric Oxide Production - COVID-19, Respiratory Infections, And Controversial Claims About Disease Prevention   **More from Dr. Nathan S. Bryan:** **Website:** n1o1.com **Instagram:** @drnathansbryan **LinkedIn:** Nathan Bryan **Facebook:** N1o1 by Pneuma Nitric Oxide **Youtube:** Dr Nathan Bryan Nitric Oxide **Get Dr. Nathan S. Bryan's Book:** The Secret Of Nitric Oxide **Get Dr. Nathan S. Bryan's Products:** n1o1.com/shop   **Leave us a Review:** https://www.reversablepod.com/review   **Need help with your gut? Visit my website gutsolution.ca to join a program:** Get help now   **Contact us:** reversablepod.com/tips    **FIND ME ON SOCIAL MEDIA:** Instagram  Facebook  YouTube