Circulatory system

Because BPC-157 works systemically, it modulates the body's nitric oxide, or NO, system.

Which is crucial for blood flow.

Exactly.

It specifically activates the AKT-ENOS axis and the ERK-1-2 pathways.

Fair point.

Yeah.

Think of ENOS as the cellular engine that creates nitric oxide that dilates your blood vessels and improves blood flow.

Okay.

I'm a urologist and we are surgeons of the pelvis and genital urinary organs.

And we are blood flow doctors.

We care about blood flow.

In order to have sex, you need to have blood flow, AKA your heart and your brain need to work.

but also genitals need blood flow.

And if you do not have blood flow, we commonly know that as erectile dysfunction, right, in the men.

But all bodies are the same.

We're just rearranged in different parts.

He's the vice president of Cardio Miracle, the heart health company that was founded by his father, John Hewlett.

Now, before we get into things like nitric oxide and blood flow and cardiovascular health, you've got to hear Josh's personal story, man, because at his heaviest, Josh weighed over 480 pounds and his health journey was built, wasn't built around like a 30 day quick fix.

It actually happened one decision, one walk and one day at a time and over 480 Over five years, Josh accumulated over 22 million steps, lost approximately 200 pounds, transforming not only his body, but the direction of his life.

And that's what really interests me.

Well, you know, I always heard I've heard I've read that, you know, dementia, Alzheimer's, it doesn't.

happen in your 60s and 70s.

It happens in your 30s and 40s when you're not sleeping well and you're staying up all night and you're not getting that blood flow, right? And so what nitric oxide, the discovery, quote unquote, of it won the Nobel Prize in Medicine in 1998 by three scientists.

And what they discovered is that What nitric oxide does is the vasodilator that opens up all your veins and arteries to help blood flow get through.

But that's probably the most serious thing.

The other symptoms would be when your two ovaries stop working, average age of in the mid 40s to 50s, average 51, it produces less estrogen and the estrogen is what's needed to increase blood flow.

It's all about the blood flow in your genital tissues because it's all about the oxygen.

If you don't have oxygen in these areas, then you'll have the symptoms that you were hinting about, the vaginal dryness, painful intercourse, the skin of the majora starts sagging, the walls of the vagina start getting weak, the prolapse of the rectum comes out, the prolapse of the bladder comes out, your bladder starts having overactive symptoms, you have to, you hear the sound of water, you drive into your driveway, you put your key in the door and you suddenly have to pee all the time.

Yeah, and you get the repetitive urine infections, your repetitive vaginal infections because the blood flow that was decreased It lowers the pH of the, I'm sorry, raises the pH of the vagina.

And it's all because of blood flow and oxygen.

Wow.

I'm going to get into blood flow and I'm glad you're bringing this up because that wasn't a conversation that we had.

Yes, so it's what you eat that shows up in everything you do, and part of that is your sex life.

And the reason is that your body needs blood flow, right? Especially your genital organs.

When you get aroused, you get blood flow to the genitals.

And in order to have good blood flow, you need to have good, healthy vessels.

And when you eat poorly, you affect those vessels and those vessels get less flexible, they get more stiff, they get clogged with cholesterol plaques, and then you're not getting good blood flow to those areas.

And what happens, unfortunately, is that very often you're seeing problems in your genitals long before you're having heart disease or any other problem.

So the reality is that it's actually a great way to sort of look at your body and say, hey, something's off here.

Like we need to go back to the basics and see what's wrong.

I know it is all good for you, but wondering if like running is better than elliptical or incline walking, for example.

I hate to use the word optimal, but I'm curious if moving more parts of your body while getting your heart rate up makes any difference to overall cardiovascular health due to more blood flow.

Thanks.

So I'll start by saying it's a really fun and interesting question.

I will say if I'm comparing the Assault bike or the Rogue Echo bike to a regular bike, one of the great things about it is it's a full body.

You get upper body tissues, lower body tissues, whereas just regular cycling is almost solely just lower body.

And I think this is leading into the question that was asked is like is there one that's better or worse because you're getting more blood flow, you're using more muscles throughout the body.

Honestly, I'm not doing cardio to provide muscular adaptations to certain tissues in my upper or lower extremity.

I was actually at a Pilates conference, and I heard an American urogynecologist was presenting, Dr. Bruce Crawford.

He was presenting his latest research in the mid-2014, 2015, and his latest research showed that 90% of pelvic floor dysfunction was a fitness issue, not a medical issue, and it was tied to this trifecta, this threesome, essentially, of poor breathing mechanics, poor posture and a lack of blood flow to these 14 muscles.

So in that moment, I was like, wait.

Because I had my Pilates studio.

Of course, for a woman, that's either vaginally or rectally.

For a man, that's rectally.

And that's precisely why I saw a huge opportunity to Going back to Dr. Crawford's research, if 90% of this is a fitness issue, why on God's green earth would we not create a fitness solution for that? And that's what I believe I did with the Cooch Ball, to help people at home sit on the ball for three minutes a day, doing their diaphragmatic breathing to start to melt through those fascial restrictions and get the blood flow, which is the muscle's nutrition, to essentially...

wake the muscle back up.

Yeah.

So if we're able to decrease our inflammation and then increase our blood flow, it seems like that's kind of the, the, the, one of the key steps into decreasing our biological age and, and aging well, and like trying to get to the point where we're living to 150.

Exactly.

It's funny.

All right.

I want to, I want to ask, remind me to come back.

Cause I want to talk about blood flow and peptides that can increase blood flow.

Cause I hear a lot of guys who are like microdosing, like Viagra Cialis, like on a daily basis as a, like a longevity thing.