Immune disorder

We call that hypoxia or ischemia.

There's always inflammation, oxidative stress, and immune dysfunction.

Nitric oxide is what regulates all those.

If you lose the ability to produce nitric oxide, you don't dilate blood vessels.

And then nitric oxide is what reduces inflammation.

It controls the inflammatory response.

It prevents oxidative stress and it corrects the immune dysfunction.

So this one molecule addresses all aspects and root cause of all chronic disease.

Thanks for having me on your show.

We're gonna talk about ALS, Koya, and its efforts to develop a therapy that targets immune dysfunction in ALS and other neurodegenerative conditions.

Well, let's sort start with ALS, though.

What is it, and how does it typically manifest itself and progress?

Uh, we're starting to understand what triggers some of these neurodegenerative diseases, and I think that's why it's taken a long, a, a little bit of time, uh, to start seeing therapies here.

But I think you're going-- I call this next decade the decade of neuroscience, and we're gonna see some breakthroughs in all of these neurodegenerative diseases.

Koya is not alone i-in looking at immune dysfunction and the role it plays in ALS and other neurodegenerative conditions.

What initially led Koya to, to focus on that biology?

But yeah, so let's talk about, we have to cover some, you know, basic science.

Uh, we'll talk about immune dysfunction, hypothyroidism, Hashimoto's, and chronic illness.

Really, when you look at w- when people get sick, old, stressed, they get a, uh, essentially an immune shift.

TH1, and you can throw Tregs over there to TH2, TH17.

I know it's a bold statement, but when you do it, it like, wow, it's kinda like, you know, of all, all these specialists, they're just missing the boat, and you'll be able to treat these patients better than the specialists.

So, I'll just quote, "The immune system health is shown to be the biggest determinant of overall health and longevity.

Toxins, stress, age, and chronic infections are major triggers of immune dysfunction, which result in the T1, Treg, the TH2, TH17 shift, and a clear correlation between the increase in mean longevity and a leading indicator of cell immunity." So everything's a vicious cycle, and I did this in two thousand three for the Fibromyalgia Fatigue Centers.

We had twenty-three centers focused on, you know, treating the sickest patients.