Nitric oxide

Right.

When you ingest dietary nitrate, your body reduces it into nitrite, NO-URO, and finally synthesizes it into systemic nitric oxide.

And epoxide, that is the famous vasodilator.

Yes, it relaxes the smooth muscle cells lining your blood vessels, causing them to widen and allow massive increases in blood flow.

But what makes nitric oxide so fascinating for ultrarunners is that this specific nitrate to nitric oxide pathway is uniquely activated under conditions of local hypoxia and metabolic acidosis.

Okay, start right there.

Why does local hypoxia and acidosis matter?

The exact moment when your legs feel like they are filled with battery acid and concrete?

And the reason is hidden within their mechanism.

Both of these are what we would consider nitric oxide scavengers.

That's how they work slightly differently, but both of them work through this nitric oxide pathway.

And nitric oxide in excess can cause refractory vasoplegia, right? Low systemic vascular resistance, poor response to standard vasopressors and refractory vasoplegia.

So how in the world does Viagra, also known as sildenafil, prevent Alzheimer's or dementia? Number one, it reduces the amyloid plaque that we see in the brains.

Number two, it enhances blood flow via nitric oxide, this gas that opens up blood vessels.

It is neuroprotective.

And it reduces the tau tangles, tau phosphorylation in the brain.

Love.

Discount code Dr. Josh, D-R-J-O-S-H.

And next is nitric oxide.

Nitric oxide I mentioned briefly with Viagra and Cialis.

Yeah, so I come from the academic world.

And so what I'd hope to do over the next hour or more is really give the listeners a conversational understanding of nitric oxide and really take you back to how it was discovered, what led to a Nobel Prize, and then where the future is.

Where's the future of medicine? And hopefully you'll be able to appreciate the importance of nitric oxide.

And the question that we pose is, is nitric oxide the key to chronic disease prevention? So what I'm going to do, and I'm not going to get too, I'm going to get a little bit technical, but I think just bear with me for those lay people out there that, because this is very important concepts that I want to present.

And I'm going to review the nitric oxide enzymology and biochemistry, and then really look at the role of nitric oxide in signaling.

And I'm going to focus on insulin signaling and metabolic disease.

as a archetypical kind of phenomenon in nitric oxide, because insulin resistance and metabolic disease, we know today nine out of 10 Americans are metabolically unfit, and the missing part of that is nitric oxide.

And then at the end, I want to show you the clinically proven strategies that can restore nitric oxide production and what's been proven to prevent the onset and progression of chronic disease.

This is where we explore an important health and fitness topic with a subject expert.

And today, we're excited to welcome Dr. Nathan Bryan to talk about nitric oxide.

Welcome, Dr. Bryan.

John, great to be with you.

Well, we appreciate you being here, spending time.

Uh, Dr. Bryan, let me just tell you a little bit about him.

He is a leading expert in nitric oxide research with over 25 years of experience.

He's made groundbreaking discoveries, and he holds numerous patents and has published 100-plus peer-reviewed articles.

An erection is the relaxation of smooth muscle that allows this sponge-like tissue to fill up with blood, and then that blood that fills up in the sponge shuts the exit door, okay? So then the blood can't leave.

And so the thing that causes an erection, which is actually the same thing that Viagra works on, is called nitric oxide.

This is the message that causes the smooth muscle to relax and allow the sponge to fill up to its full capacity.

Big question is, what is causing the decrease of nitric oxide? Now, if we take an 18-year-old versus a 70-year-old, we get a huge drop in nitric oxide.

A 70-year-old has a drop of nitric oxide by 75%.

So you can now see where the problem is.

As we age, we make less nitric oxide.

So a lot of people ask me, "What supplements do I recommend?" Now, of course, I'm not biased of my own high-quality supplement line, but if you go to Amazon and type Dr.

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We've got a great doubleheader.

We've got a couple of business superstars here with me.

The following week, I'm keeping up my Mayor of Naperville tradition, Mayor Scott Worley from Naperville, a great community number one.

area in the country people want to live, great sports programs, great wellness programs.

And then one of my newest supporters and advertisers, Brian Therapeutics, Dr. Nathan Bryan, the whole world of nitric oxide.

It's such a big deal.

It runs on oxygen.

It runs on a chemical messenger called nitric oxide, which is the molecule that tells your blood vessels, including the ones feeding your brain, to open up and deliver oxygen.

When the nitric oxide is there, blood flows.

When the blood flows, the brain gets what it needs to think clearly, to sleep well, to regulate fear, to steady the nervous system after stress.

When nitric oxide is not there, all of that gets harder.

And I'm not going to tell you that a supplement cures anything.

I'm not allowed to say that.

If somebody promises you that, you got to run the other way.