RCT shows striking reversals
Here’s what the new trial revealed
Mar 24, 2026 · 1 hr 59 min · 29 segments
Neurologist Dr. Dale Bredesen shares clinical evidence that cognitive decline can be prevented — even reversed. Show partners: LMNT - Claim your free LMNT Sample Pack with any purchase by using…
Well, the way I understand it, you've done a bunch of research leading up to this paper, but this is-
So let's talk about the layout of this study, and then what you can share at this point, what you found.
Yeah, you made a great point, which is that you, you-- ultimately, this is the gold standard.
So the anecdotes showed that again and again and again, we could see reversal of cognitive decline, which just hadn't been reported before.
That was a peer-reviewed paper to show that, yes, we can reverse cognitive decline.
Then there was independent confirmation by Dr. Heather Sandison and her team that came out in 2024, uh, and that was showing that, yes, you know, you, same sort of thing.
They saw very much the same thing we did, that you could reverse cognitive decline.
So then we finally-- that all of those led up to this randomized controlled trial.
Now, people have argued that, you know, how is it ethical to do a trial now that we know what we know? How is it ethical to do a trial where you have people who are getting standard of care when the standard of care is not showing reversal of cognitive decline? So what we do is th- this is a nine-month trial, and so you either, you randomize two to one.
So there's a 67% chance you'll get in the treatment group and a 33% chance that you'll get in the standard of care group.
They can have a free six months of being, uh, in the, uh, of being, uh, given the, the precision medicine approach, where we're looking at all these things.
And, and, and you could see, in fact, the people who are in the standard of care going downhill and then bouncing up and improving after they got on-The treatment.
Well, the way I understand it, you've done a bunch of research leading up to this paper, but this is-
So let's talk about the layout of this study, and then what you can share at this point, what you found.
Yeah, you made a great point, which is that you, you-- ultimately, this is the gold standard.
So the anecdotes showed that again and again and again, we could see reversal of cognitive decline, which just hadn't been reported before.
That was a peer-reviewed paper to show that, yes, we can reverse cognitive decline.
Then there was independent confirmation by Dr. Heather Sandison and her team that came out in 2024, uh, and that was showing that, yes, you know, you, same sort of thing.
They saw very much the same thing we did, that you could reverse cognitive decline.
So then we finally-- that all of those led up to this randomized controlled trial.
Now, people have argued that, you know, how is it ethical to do a trial now that we know what we know? How is it ethical to do a trial where you have people who are getting standard of care when the standard of care is not showing reversal of cognitive decline? So what we do is th- this is a nine-month trial, and so you either, you randomize two to one.
So there's a 67% chance you'll get in the treatment group and a 33% chance that you'll get in the standard of care group.
They can have a free six months of being, uh, in the, uh, of being, uh, given the, the precision medicine approach, where we're looking at all these things.
And, and, and you could see, in fact, the people who are in the standard of care going downhill and then bouncing up and improving after they got on-The treatment.
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