Randomized controlled trial
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Search complete. 414 mentions across 194 episodes found for "Randomized controlled trial".
Sep 11, 2026
Erin McCrearyHOST
And I think it's an inferior antibiotic when you compare it to nitroferantoin or trimethoprim sulfamethoxazole.
Erin McCrearyHOST
And we have RCTs to show that.
Erin McCrearyHOST
so then you take and then you try to apply that to like any other reason someone would use phosphomycin and we know it you know and then the susceptibility testing is a nightmare as you've described you know e coli maybe enterococcus faecalis but you can't really reliably test it against any other organisms you don't even know and just the whole and for prostatitis i admit i have not deep dove into this so i'm not sure but just like the pkpd standpoint of it how would this even work i have to wrap my head around it but That being said, chronic bacterial prostatitis is uncomfortable for patients.
Erin McCrearyHOST
They want to be cured with certainty, but it's not something they're going to actively die tomorrow.
Jean-Claude BrizardGUEST
But I mean, I want to go back to the piece you had even pushed on evidence.
Jean-Claude BrizardGUEST
You know, we don't need RCTs, right, for edtech efficacy.
Jean-Claude BrizardGUEST
There are ways to do this.
Jean-Claude BrizardGUEST
There are simple tools that we know exist in the market, like the edtech index that is the answer that's actually published.
Jean-Claude BrizardGUEST
But I mean, I want to go back to the piece you had even pushed on evidence.
Jean-Claude BrizardGUEST
You know, we don't need RCTs, right, for edtech efficacy.
Jean-Claude BrizardGUEST
There are ways to do this.
Jean-Claude BrizardGUEST
There are simple tools that we know exist in the market, like the edtech index that is the answer that's actually published.
Lance WheelerHOST
The clinical meaning is that high-dose buprenorphine can perpetuate postoperative hyperthermia for many hours.
Lance WheelerHOST
A 2022 study titled High-Dose Buprenorphine Results in a Greater Occurrence of Postoperative Hyperthermia than Morphine in a Randomized Clinical Trial in Cats Undergoing Ovarian Hysterectomy by Manuel Martin Flores et al.
Lance WheelerHOST
evaluated 94 client-owned cats.
Lance WheelerHOST
Cats were randomized to buprenorphine 0.2 mg per kg sub-Q or morphine 0.1 mg per kg sub-Q during recovery.
Amy VoedischHOST
So it was a little bit muddy to kind of see what's there.
Rebecca Dunsmoor-SuHOST
I took a deeper look at some of these small RCTs, and really, you know, they're all underpowered.
Rebecca Dunsmoor-SuHOST
They really don't have the number of patients you need to get some sort of real solid feel for the data.
Rebecca Dunsmoor-SuHOST
But the other thing that I saw with all these modest benefits they were showing, I had to ask myself, is it because they're too small to detect, you know, that modest benefit? Or is it possible that it just differs person to person? So when you put all those people together, the average effect is pretty low.
speaker_3HOST
Yes.
speaker_3HOST
The highest quality RCTs demonstrate a distinct, measurable advantage for mica in the first 6 to 12 weeks post-operatively.
Mohamed ImamHOST
What does that look like for the patient?
speaker_3HOST
Patients undergoing MICA consistently report much lower immediate post-operative VAS scores.
David BosanquetGUEST
I would say that the evidence for epidurals is partly there, but it's not overwhelming.
David BosanquetGUEST
So, for example, I believe this is a 65 patient RCT, which does suggest that if you give an epidural or if you give something else preoperatively, which can improve your pain experience, then you do get improved outcomes in terms of phantom pain afterwards.
David BosanquetGUEST
I guess the challenges with epidural are actually myriad, right? You have issues such as there's risks to them.
David BosanquetGUEST
There's the challenge of actually finding an individual who's got time and space to insert them.
14 MINS LATER
David BosanquetGUEST
That muscle has to have been taken away from the innovation which it currently has.
David BosanquetGUEST
If you place a nerve within muscle that's already innovated, It doesn't have an area to grow into, but if it's not innervated by nerve, then the idea is that as the nerve heals, it will heal into the muscle and it will actually create connections to that muscular tissue itself, which will then support more ordered firing rather than disordered firing in the symptoms with neuromas.
David BosanquetGUEST
And so RCTs have demonstrated that this can be a very effective treatment for symptomatic neuromas, RPNI, as well as potentially for patients having primary amputations.
David BosanquetGUEST
The other plastic surgical technique that has come onto the scene over the last few years is TMR.
speaker_0HOST
They dismissed EERW as invalid.
speaker_0HOST
They demand randomized controlled trials, even though long-term RCTs are unethical and impossible for chronic opioid therapy.
speaker_0HOST
They know that.
speaker_0HOST
They just hope that you don't.
Sonia SinghHOST
in patients with diabetes, because there is good evidence for benefit with these patients.
Sonia SinghHOST
So the first one I'll share is called Effects of Continuous Glucose Monitoring on Metrics of Glycemic Control in Diabetes, a Systematic Review with Meta-Analysis of Randomized Controlled Trials.
Sonia SinghHOST
So this meta-analysis and systemic review, the randomized controlled trials that they assessed were looking at changes in A1c, time spent in the target blood sugar range, so TIR, Time spent below the target range, so TBR, that's if the blood sugar is too low, and time above target range, meaning blood sugar is too high.
Sonia SinghHOST
And it was showing the impact of using a CGM on those metrics for these patients.
Sonia SinghHOST
And these were all patients who had either type 1 or type 2 diabetes who were on insulin.
Sonia SinghHOST
And so that's a...
Sonia SinghHOST
That's just an important caveat because I think that impacts access for a lot of people to these devices.
Sonia SinghHOST
So this study that I'm going to cite was continuous glucose monitoring in non-insulin treated type 2 diabetes, a critical review of reported trials with an updated systematic review and meta-analysis of randomized controlled trials.
Spring HatfieldNARRATOR
Researchers and dental professionals want and need to know which approach to Carrie's treatment on primary teeth is the best for their practices and child patients.
Spring HatfieldNARRATOR
Children's and parents' perspectives on the acceptability of three management strategies for dental caries and primary teeth within the filling children's teeth indicated or not, Fiction Randomized Controlled Trial, a qualitative study by Sarab Alyosfi, Nicola P. Inez, and colleagues, began as a breakdown of strategies to discover which one was the most efficient and effective with children.
Spring HatfieldNARRATOR
Throughout the discovery time, the researchers realized that their study reflected much more than information on management strategies.
Spring HatfieldNARRATOR
Fiction management strategies.
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