Urolithin A
CompoundWikipedia
104
MENTIONS
27
EPISODES
27
PODCASTS
Search complete. 104 mentions across 27 episodes found for "Urolithin A".
Sep 21, 2026
Felice GershGUEST
Pomegranates, which has, you know- Has fame as a superfood.
Felice GershGUEST
Pomegranates have ellagic acid, another phytoestrogen from which derive urolithins A and B.
Felice GershGUEST
So most all the foods that are known as superfoods and health foods, oh, they're really phytoestrogens, these magical ingredients that are not estrogens, but they combine to estrogen receptors and help to make the body and every organ system healthier.
Felice GershGUEST
But by combining lifestyle approaches, like what you eat and exercise, which will trigger the production of the sirtuins, as well as fasting.
Ken BerryHOST
So pomegranates.
Ken BerryHOST
Now, if you just read that title and you were starting to get forgetful, what would you do next time you went to the grocery store? Buy some pomegranates, right? Experts explain how urolithin A, a substance found in pomegranates, may boost brain health.
Ken BerryHOST
So let's highlight this.
Ken BerryHOST
Urolithin A, a substance found in pomegranates.
Ken BerryHOST
Remember that.
Ken BerryHOST
This is gonna become important in just a minute, okay? So here's the article.
Ken BerryHOST
Again, they say a substance found in pomegranates known as urolithin A may improve memory.
Ken BerryHOST
So at least they say may, which equals may not.
Will ColeGUEST
And then some compounds that I would say that science shows to be helpful for mitophagy a- are postbiotics.
Will ColeGUEST
There's one called urolithin A-
Darshan ShahHOST
Yes
Will ColeGUEST
... which I know you know.
Darshan ShahHOST
Exactly.
Will ColeGUEST
All that.
Darshan ShahHOST
I'm a big fan of Timeline, uh, urolithin A-
Will ColeGUEST
Yes
Josh AxeHOST
Like, what does the mitochondrial need to be healthy, right? Of course, it needs sleep.
Josh AxeHOST
That's a big deal, but it also needs, uh, this thing, ellagic acid or urolithin A, right?
Will ColeGUEST
Mm.
Josh AxeHOST
PQQ, NAD+, right? A lot of these sort of, you know, in, in...
25 MINS LATER
Will ColeGUEST
There's a few other nutrient-dense foods that have this unique spermidine, because fasting increases autophagy, but so does spermidine.
Josh AxeHOST
Mm-hmm.
Will ColeGUEST
Urolithin A is another one, which you mentioned earl- earlier.
Will ColeGUEST
We can get it from these polyphenols, like ellagic acid, that's in things like pomegranates.
Christian GonzalezHOST
They work on inflammation.
Christian GonzalezHOST
But the next one that I go into actually goes into the power plants inside your cells That is urolithin A. Urolithin A is amazing.
Christian GonzalezHOST
If what you feel aging the most in your life is your strength, your recovery, your energy, urolithin A is for you.
Christian GonzalezHOST
This is an exciting one because it triggers a process in your cells called mitophagy.
Christian GonzalezHOST
Mitophagy is a clearing up of old, broken up mitochondria.
Christian GonzalezHOST
It improved endurance.
Christian GonzalezHOST
It lowered inflammation.
Christian GonzalezHOST
If the label says urolithin A, ideally, you want 500 to 1,000 milligrams.
Claudia GilaniHOST
Absolutely.
Claudia GilaniHOST
How do you feel about urolithin A? Are you a fan? Do you see any difference with people using it?
Lauren PapanosGUEST
I don't, unfortunately.
Lauren PapanosGUEST
I really don't.
Lauren PapanosGUEST
The thing is, is like any of these mitochondrial supplements, I mean, even NAD, is if you don't address the mitochondrial cofactors and the oxidative stress piece before you add them in, they're just not going to really move the needle because you're just adding in support at like the wrong step in the process.
Lauren PapanosGUEST
Um, so I find that sometimes I've even found, especially in some of my post COVID patients that when they add in things like urolithin A and NAD, they get really sick.
Lauren PapanosGUEST
Like it, it actually has the opposite response that happens in their body.
Lauren PapanosGUEST
Um, and kind of similar as like the antioxidants, like you mentioned is that or just throwing off that whole redox balance in the cell.
Mamina TureganoGUEST
... and for skin health too, so I said collagen peptides.
Mamina TureganoGUEST
I am a fan of Urolithin A.
Mamina TureganoGUEST
You know, Timeline-
Anastasia KhodjaevaHOST
Mm-hmm
Amitay EshelHOST
About different urolithins, right? Like, actually w- you know, talking about cancer, most of the exciting rec- exciting reser- research is about urolithin B.
Anastasia KhodjaevaHOST
Mm.
Amitay EshelHOST
And, uh, I believe I might be, like, um, I might be off on my dates, but I think, um, BioLite came out with, uh, with urolithin A and B already.
Amitay EshelHOST
And I, again, I don't know what Timeline, what Timeline's timeline is.
Carl PrudelliHOST
Hominix P30 just has a strong library of scientific backing and support.
Carl PrudelliHOST
Now, one of the key longevity supplement ingredients that's been attracting a lot of attention is a synthetic form of urolithin A, which we don't get much of from diet.
Carl PrudelliHOST
but can be made, you know, in our guts.
Carl PrudelliHOST
Now to start a material for making urolithins are some of the polyphenols that are naturally found in pomegranate fruit.
Andrea ZangaraGUEST
And Pomonox supports this process by supplying standardized polyphenol precursor, which is really
Carl PrudelliHOST
important.
Andrea ZangaraGUEST
And we have studies measuring urolithin A metabolites after pomanoxin intake.
Andrea ZangaraGUEST
And in those studies, we have detected these metabolites, confirming that this transformation can occur in most people.
Siobhan MitchellGUEST
It's still mysterious.
Siobhan MitchellGUEST
So it seems like, yeah, if you're a Western woman, it's a little bit like the Urolithin A story.
Siobhan MitchellGUEST
You're probably just best off finding an S-equal supplement and using that.
Kara FitzgeraldHOST
Yeah.
Kara FitzgeraldHOST
I just-- I mean, I've, I've, I've, I've been a huge fan of it for a long time.
Kara FitzgeraldHOST
And I also am curious to see whether I make it or not, so I might check that lab.
Kara FitzgeraldHOST
But I, I, I think even if I did, you know, thinking about the Urolithin A stories, that we l- probab- I pro- I-- well, A, I don't eat enough soy.
Kara FitzgeraldHOST
It's not, it's not a standard food in my diet.
James O'DellHOST
That requires much more research.
James O'DellHOST
Another compound I use is urolithin A. Urolithin A has attracted interest because of its relationship with mitophagy, the mitochondrial housekeeping process we discussed earlier.
James O'DellHOST
It appears to influence signaling involved in identifying and clearing dysfunctional mitochondria.
James O'DellHOST
Again, the biological mechanism is fascinating, but research into its long-term effects on human aging is still developing.
17 more episodes mention Urolithin A.
Create an account to see the whole feed, search across every transcript, and follow the entities you care about.