Redefining Oral Therapy in Psoriasis: TYK2 Inhibition in Focus

So let's talk first about a couple of cases.

And this is case one.

This is Marcus, 42 years old.

He has extensive disease, three-year history of plaque psoriasis.

It's on his trunk and extremities.

It's been worsening in the last year despite consistent use of over-the-counter topicals.

He's got about 18% BSA.

So poor Marcus should not be just using over-the-counter topicals.

He is embarrassed.

He avoids the gym, and he's gained some weight because he stopped going to the gym.

Quote from him here, he's had a lifelong fear of needles.

He know it isn't great, but I never get a flu shot.

I could probably force myself to do it, but if that's the only option.

So now we're going to move to Priya.

She's 29 years old.

She has high impact site involvement.

She has it in her vulva, perianal skin, and inguinal folds.

It's only about 3% BSA, but again remember high impact area.

She's been using a lot of topical therapies, has resulted in adverse events leading to discontinuation.

Persistent burning, pruritus interfere with her daily activities and she's embarrassed by this.

She wants the symptoms to stop.

She wants to feel normal again.

She can't keep waiting weeks to feel better and it's affecting her everyday life.

And then we have David, he's 55 and topicals aren't enough for him.

Chronic plaque psoriasis, he has about 7% BSA.