Oct 2, 2026 · 22 min · 10 segments
In this episode, I discussed a case of Gastric/Duodenal ulcer perforation- how to diagnose and treat a case. If you sincerely listen this podcast you will learn everything about the case.
Yeah, this is Mr. Rajan, our 55-year-old patient.
And just looking at his history, it's basically a biochemical disaster waiting to happen.
It's the perfect storm.
I mean, those risk factors, they just completely dismantle the stomach's defenses.
Like, how do NSAIDs and smoking actually break down the mucosal barrier? I mean, the stomach is built to handle acid.
It is, yeah.
It's a marvel, honestly.
The stomach balances really aggressive acid like pH of 1.0 against a thick, bicarbonate-rich mucus layer.
But that defense is active.
It takes energy.
Exactly.
And the main drivers of that defense are prostaglandins, specifically from the CuX1 pathway.
So he's fixing his knee pain, but he's secretly stripping his stomach of its armor.
You nailed it.
The mucus production drops, the bicarb stops, and worst of all, the blood flow to the tissue decreases.
Yeah, this is Mr. Rajan, our 55-year-old patient.
And just looking at his history, it's basically a biochemical disaster waiting to happen.
It's the perfect storm.
I mean, those risk factors, they just completely dismantle the stomach's defenses.
Like, how do NSAIDs and smoking actually break down the mucosal barrier? I mean, the stomach is built to handle acid.
It is, yeah.
It's a marvel, honestly.
The stomach balances really aggressive acid like pH of 1.0 against a thick, bicarbonate-rich mucus layer.
But that defense is active.
It takes energy.
Exactly.
And the main drivers of that defense are prostaglandins, specifically from the CuX1 pathway.
So he's fixing his knee pain, but he's secretly stripping his stomach of its armor.
You nailed it.
The mucus production drops, the bicarb stops, and worst of all, the blood flow to the tissue decreases.
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