immunosenescence

Now, that's the concept of, of, let's say, cellular senescence.

Immunosenescence to a, to a certain concept is really as the thymus involutes, you're dealt with whatever immune cells are left in your body.

There are no new ways to sort of regrow the thymus.

Maybe that's one way, and there are companies thinking about regrowing thymus.

And I'd say from a basic science perspective, I mean, IL-31 binds to the peripheral nervous system in terms of directly submitting these itch signals, right? But there is a particular enrichment of IL-31 receptors in the dorsal root ganglia.

So even if this is like a neuropathic process, like it can work in purely neuropathic itch, if there's that component of like, you know, immunosenescence, TH2 shift, it's working in that too.

So I find that it's like magic in these patients.

It's really, really,

So really, immune health is the biggest determinant of your health, okay? So you have all these things that are very similar.

Immunosenescence, cellular senescence, T-cell exhaustion, inflamma-aging.

Really major focus on disease prevention, and we're now, you know, using, uh, it's big with longevity.

You get rid of these senescent cells, you live longer, less disease.

Projections by World Health Organization report predict that by 2030, one in six people globally will be over 60 years of age.

It is important to be aware of this because of immunosenescence.

Immunosenescence is the gradual deterioration and remodeling of the immune system that occurs naturally with aging.

And because of aging, the immune system cannot respond as effectively or as dynamically as the younger counterpart, which is as a result of decreased output of effector cells.

And this leads to a higher risk of infectious diseases, including tuberculosis.