Mar 17, 2026 · 1 hr 19 min · 12 segments
TWiN explains the role of a ubiquitin ligase component in regulating the sheathing of multiple axons by Schwann cells. Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung Subscribe…
Vivianne MorrisonHost
Tim CheungHost
Vincent RacanielloHostSo the paper was published in Nature Communications in 2019 by Kelly Monk's group.
And there are two other names here at the end that are pretty famous in the glia field.
Um, so right off the bat, we're going to be returning to something that I talked about when I first came onto the show, um, which, uh, which are glial cells, um, and even more specifically myelinating glial cells.
And I actually think a lot of listeners will know what it is because, um, you know, we No, like I think pretty much everybody knows somebody who suffers from multiple sclerosis, which is an autoimmune disease where the immune system targets myelin and the cells that create it.
So people know what myelin is, generally speaking, but basically it's a lipid-rich, fat-rich coating on the axon, which is the structure of the neuron that allows the electrical signal to go from one place to its destination from the cell body.
It's like an electrical wire, you know, being insulated so that the electrical signal can like get from point A to point B and it can do it quickly and, you know, high fidelity.
And Yeah, so I should say that the first author of this paper is Brianne Hardy.
So myelin is these concentric layers of cell membranes, mostly lipids, some proteins.
And like I said, it helps the electrical signals travel more quickly and with higher fidelity to their destination, which is the presynaptic terminal.
And not all axons are myelinated and not even in the central nervous system and even in the peripheral nervous system.
So the paper was published in Nature Communications in 2019 by Kelly Monk's group.
And there are two other names here at the end that are pretty famous in the glia field.
Um, so right off the bat, we're going to be returning to something that I talked about when I first came onto the show, um, which, uh, which are glial cells, um, and even more specifically myelinating glial cells.
And I actually think a lot of listeners will know what it is because, um, you know, we No, like I think pretty much everybody knows somebody who suffers from multiple sclerosis, which is an autoimmune disease where the immune system targets myelin and the cells that create it.
So people know what myelin is, generally speaking, but basically it's a lipid-rich, fat-rich coating on the axon, which is the structure of the neuron that allows the electrical signal to go from one place to its destination from the cell body.
It's like an electrical wire, you know, being insulated so that the electrical signal can like get from point A to point B and it can do it quickly and, you know, high fidelity.
And Yeah, so I should say that the first author of this paper is Brianne Hardy.
So myelin is these concentric layers of cell membranes, mostly lipids, some proteins.
And like I said, it helps the electrical signals travel more quickly and with higher fidelity to their destination, which is the presynaptic terminal.
And not all axons are myelinated and not even in the central nervous system and even in the peripheral nervous system.
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