More Than BRCA: Understanding Hereditary Breast Cancer Risk with Dena Goldberg

The Positive Gene Podcast | Hereditary Breast Cancer Series, Episode 1 When we hear about hereditary breast cancer, BRCA1 and BRCA2 are often the first genes that come to mind. But hereditary breast cancer risk is much more complex, and understanding your genetic information can make a significant difference in how you approach your health. In the first episode of our 10-part hereditary breast cancer series, host Sara Kavanaugh welcomes Dena Goldberg, MS, CGC, a board-certified genetic counselor, science communicator and founder of Malibu Genetics Concierge, also known as Dena DNA. Dena brings years of experience in cancer genetics, patient education and advocacy to a conversation designed to make genetics more understandable for anyone navigating hereditary cancer risk. Together, Sara and Dena explore what makes cancer hereditary, why a family history of cancer doesn't always tell the whole story, and what genetic testing can and cannot tell us about our future health. They also discuss genes beyond BRCA, including CHEK2, ATM and PALB2, the importance of understanding variants of uncertain significance (VUS), and why genetic test results should be interpreted alongside personal and family history. Drawing on her own experience living with Lynch syndrome and a CHEK2 variant, Sara shares the questions and challenges that can arise even years after receiving a positive genetic test result. In this episode, we discuss - The difference between hereditary, familial and sporadic cancer - Why someone can carry a hereditary cancer mutation without an obvious family history - How breast cancer risk differs across genes and even specific variants - Who should consider genetic testing and how to access genetic counseling - Understanding positive, negative and uncertain genetic test results - The difference between inherited (germline) and tumor (somatic) genetic testing - Sharing genetic information with family members and cascade testing - Building a healthcare team, finding reliable resources and making informed decisions over time About our guest Dena Goldberg, MS, CGC, is a board-certified genetic counselor and science communicator who makes genetics approachable through education, social media and her work with patient communities. Known online as Dena DNA, she creates educational videos, explainers and resources to help people better understand genetic testing and inherited health conditions. Connect with Dena: - Instagram: @dena.dna - TikTok: @denadna - YouTube: @DenaDNA - Website / genetic counseling information: https://www.denadna.com/ Resources mentioned in this episode Genetic testing and counseling - JScreen: https://www.jscreen.org/ - JScreen Promo Code: Use code DENADNA to get $10 off your testing kit. Genetic information and variant updates - ICARE Registry: https://inheritedcancer.net - PROMPT Registry: https://promptstudy.info/ (https://www.genomeconnect.org/) - My Gene Counsel / Living Lab Report: \[https://www.mygenecounsel.com/ - ConnectMyVariant: https://connectmyvariant.org/ - Citizen Genetics: https://www.citizengenetics.co/ - National Comprehensive Cancer Network (NCCN): https://www.nccn.org/patientresources/patient-resources Community support - FORCE (Facing Our Risk of Cancer Empowered): https://www.facingourrisk.org - The Breasties: https://thebreasties.org/ - We Got This, cancer gift registry: https://wegotthis.org/ A little something extra: the DNA headband! If you're watching the video version, you may notice Sara wearing a genetics-inspired headband from Lilac Market Headbands. After seeing Dena share the brand on Instagram, Sara ordered the DNA-print design, which arrived just in time for their recording! Check out Lilac Market Headbands and use code DenaDNA for a discount.  Click HERE to order. *This is a product mention inspired by Dena's social media post. No paid sponsorship of this episode is indicated.* About this series This episode launches a 10-part series exploring the medical and personal experiences of living with hereditary breast cancer risk. Through conversations with genetic counselors, physicians, advocates, previvors and survivors, we'll explore risk assessment, high-risk screening, preventive surgery, decision-making and the emotional realities of living with increased risk. Our goal is to help you better understand your options, ask informed questions and work with your healthcare team to make decisions that are right for you. Follow The Positive Gene Podcast so you don't miss the next conversation. Medical disclaimer This podcast is intended for education and awareness only and does not provide individualized medical advice. Genetic risk, screening recommendations and preventive options vary by individual. Please consult a qualified healthcare professional or genetic counselor about your personal and family history. Host: Sara Kavanaugh | The Positive Gene Podcast Website: https://www.sarakavanaugh.com Instagram: @positivegenepodcast