The $101 Million Aging Challenge
A global competition is testing new therapies
The Mind-Gut Conversation Podcast
Sep 19, 2026 · 1 hr 7 min · 26 segments
Over the past century, average lifespan in Western countries has grown by about 30 years. The years we spend in good health have not kept pace. In this episode of The Mind–Gut Conversation, Dr. Mayer…
Jamie JusticeGuestYeah, so I mean, you know, on this topic, so first of all, would that be desirable? This wouldn't leave any place for young people.
You know, there would be no place for jobs and no need for young people because the older generation would just reproduce or, you know, stay around for hundreds of years.

I still think I think we still currently need to adapt our societies to give a better place for all people is that I think it would require us to change our perception of what purpose means at each stage of life.

We already have young people who are coming out of jobs who can't find new ones.

You know, in the U.S., certainly the biggest economic return that we've had recently because of this population and demographic shift is that in the U.S., where we don't have a capped retirement age, people are staying in the workforce longer and that there are major economic returns because of that.

And but then when people retirement in particular, you know, data is not good.

And so that's, you know, is and that part of that is not just driven by the retirement itself, but also the stressor, the sense of purpose and and how we define life at older ages has really has we have not we have not shifted our mindset.

And so how far we extend the lifespan versus health span, yes, it might exacerbate some of those pressures where we can't ignore it.

But I would argue that by ignoring it already for the generations that are here now, we have done them a terrible disservice.

And we've done a disservice for the young people that are also trying to intermarket.
Yeah, and there's obviously, you know, another major, I mean, this will be a totally different topic, but a major competing force that goes kind of in the same direction question, you know, I mean, do we need people to live into the hundreds or two hundreds? I mean, the whole AI revolution, you know, some people predict there's no need for people anyway, you know, I mean, so...
I mean, there's several of these developments, technological developments and scientific developments that are kind of converging, you know, and I think it will need a redefinition of what it is humans, what are the values and, you know, what do you want to reach? Your pants.

And most of it's in between is that, you know, a lot of it's just gray and we're not good at gray area.

It's just not same as we're not good at prevention and we're not good at like scale for us can be hard.

Like, so for me, you know, with data and IIs that I see a lot of promise and potential of what can be developed and driven with that.

But I also know that there's also a lot of trepidation and fear, especially as we're transitioning.

And with longer lifespans, the need to be flexible and resilient through transitions also increases.
Yeah, so I mean, you know, on this topic, so first of all, would that be desirable? This wouldn't leave any place for young people.
You know, there would be no place for jobs and no need for young people because the older generation would just reproduce or, you know, stay around for hundreds of years.

I still think I think we still currently need to adapt our societies to give a better place for all people is that I think it would require us to change our perception of what purpose means at each stage of life.

We already have young people who are coming out of jobs who can't find new ones.

You know, in the U.S., certainly the biggest economic return that we've had recently because of this population and demographic shift is that in the U.S., where we don't have a capped retirement age, people are staying in the workforce longer and that there are major economic returns because of that.

And but then when people retirement in particular, you know, data is not good.

And so that's, you know, is and that part of that is not just driven by the retirement itself, but also the stressor, the sense of purpose and and how we define life at older ages has really has we have not we have not shifted our mindset.

And so how far we extend the lifespan versus health span, yes, it might exacerbate some of those pressures where we can't ignore it.

But I would argue that by ignoring it already for the generations that are here now, we have done them a terrible disservice.

And we've done a disservice for the young people that are also trying to intermarket.
Yeah, and there's obviously, you know, another major, I mean, this will be a totally different topic, but a major competing force that goes kind of in the same direction question, you know, I mean, do we need people to live into the hundreds or two hundreds? I mean, the whole AI revolution, you know, some people predict there's no need for people anyway, you know, I mean, so...
I mean, there's several of these developments, technological developments and scientific developments that are kind of converging, you know, and I think it will need a redefinition of what it is humans, what are the values and, you know, what do you want to reach? Your pants.

And most of it's in between is that, you know, a lot of it's just gray and we're not good at gray area.

It's just not same as we're not good at prevention and we're not good at like scale for us can be hard.

Like, so for me, you know, with data and IIs that I see a lot of promise and potential of what can be developed and driven with that.

But I also know that there's also a lot of trepidation and fear, especially as we're transitioning.

And with longer lifespans, the need to be flexible and resilient through transitions also increases.
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3 of 11
The $101 Million Aging Challenge
A global competition is testing new therapies
How Long Could Humans Live?
Scientists model possible lifespans far beyond today
Aging Is The Chain
Aging may be the system, not disease
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