Lambert-Eaton myasthenic syndrome

which when tested by radiomino assay, we have shown that titers above 0.4 nanomoles per liter are the ones which are strongly associated with autoimmune autonomic dysfunction and lower titers can be non-specifically seen in various diseases.

The same can be true for other antibodies, such as the TQ-type calcium channel antibody associated with Lambert-Eaton myasthenic syndrome.

And then lastly, as I was saying, especially for these multifocal manifestations, the specimen type sometimes ends up being useful.

We may all be aware that for an MDA, serum can generate a lot of false positives.

What if sudden leg weakness or severe fatigue wasn't just stress or aging, but your body's immune system sounding an early alarm for a hidden lung cancer? That sounds pretty scary.

Today, we're [laughs] uncovering Lambert-Eaton myasthenic syndrome, that's a mouthful, thank you, or LEMS.

I usually don't like initials, but in this case, please, thank you, LEMS.

It's a rare condition where over 90% of the cases are missed or misdiagnosed.

The real exception is very narrow and very specific.

So if someone has a connection between nerves and muscles directly, so if someone has myasthenia gravis and a related condition called Lambert-Eaton syndrome, which I've never seen, those carry an actual FDA-based warning because the toxin can genuinely worsen muscle weakness in those specific populations.

So myasthenia gravis is an autoimmune condition.

I've never seen Lambert-Eaton syndrome, but I would imagine it's very similar.

In one published case series of people with undiagnosed myasthenia gravis, all eight developed real weakness after treatment.

But among patients whose myasthenia gravis was already diagnosed and well-managed, eight of 10 tolerated treatment just fine once the dose was adjusted down.

Always have in the back of your mind a potential need for post-operative ventilation on ICU for these patients.

The other condition which you may come across is Lambert-Eaton myasthenic syndrome.

This time, the autoantibodies are against the voltage-gated calcium channels in the presynaptic membrane, resulting in proximal muscle weakness which improves after periods of muscle contraction.

In the management of these patients, always remember to screen for underlying malignancy as the condition is highly associated with paraneoplastic syndrome.