Avi Mash hosts Iovance ($IOVA) investor Minnesota Gopher and trader Father of Trades to discuss Iovance's IL-12 tethered TIL program, Amtagvi data in melanoma, non small cell lung cancer, endometrial cancer and sarcoma, FDA CNPV vouchers, a possible Merck buyout, and short selling in biotech. Father of Trades reviews the $IOVA chart and options chain and compares it to $SLS. Minnesota Gopher expects 18 to 22 by year end, and over 30 if a voucher basket is accepted.
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Chapters:
0:00 Intro music
4:43 Minnesota Gopher on $IOVA and biotech short selling
15:37 IL-12 tethered TIL: holy grail of cancer therapy
22:19 Amtagvi frontline push and Keytruda style expansion
24:54 Biotech lagging the market and AI in medicine
29:06 FDA timelines, China drugs and CNPV vouchers
36:08 Iovance buyout, Merck and global distribution
44:04 Lung, melanoma, endometrial and sarcoma TIL data
56:23 $IOVA chart, volume profile and key levels
1:04:10 $IOVA options chain, open interest and gamma ramp
1:14:45 $IOVA price targets and the $SLS comparison
1:24:21 Father of Trades on BlackBerry QNX and holding winners
Key takeaways:
\- Minnesota Gopher calls Iovance's IL-12 tethered TIL a potential holy grail because, in his view, it could turn cold tumors hot and make them treatable.
\- Minnesota Gopher cited company figures: a 64.3% response rate in EGFR non small cell lung cancer with Keytruda and a 65.2% response rate in frontline melanoma with Keytruda.
\- Minnesota Gopher believes Iovance's new FDA and regulatory hires point to a basket submission for CNPV vouchers in non small cell lung cancer, endometrial cancer and sarcoma, and he named Merck as the likeliest acquirer.
\- Father of Trades read the options chain as pinning $IOVA near $14 in the short term and said a move above $20 could set up a gamma squeeze, as he saw in $SLS.
\- Father of Trades said scalping profits should be parked in high conviction companies and gains should be protected by taking back cost basis on 10x or 15x winners.
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