Rotations 2.0 Episode 80 Dementia

Send us Fan Mail Episode 80 Dementia Shoot me any comments or questions @Rotation2ptoh  on X Intro Music: KI Instrumental (Rock Celtic) by Lyrium-2025 Outro Music: Inspired to Begin by Alex Grohl Courtesy of Pixabay under Creative Commons non-commercial use. Produced by: Todd Fredricks DO MSS  Edited by: Todd Fredricks DO MSS  Answers for Episode 79  Substance Use Disorder  Question 1 A 32-year-old man presents with agitation, tachycardia, and euphoria after using a recreational drug. Laboratory studies show elevated extracellular dopamine levels in the brain. Which of the following mechanisms best explains the primary neurochemical action of cocaine that produces these effects? C. Inhibition of the dopamine transporter leading to increased extracellular dopamine Question 2  A 45-year-old patient with opioid use disorder is found unresponsive with respiratory depression after injecting fentanyl. Emergency medical services administer naloxone, but repeated doses are required to maintain respiration. Which of the following best explains this phenomenon? C. Naloxone has a shorter half-life than fentanyl and may require repeated dosing Question 3  A research study investigates synaptic changes in the brains of individuals with substance use disorder. Investigators find that repeated exposure to cocaine leads to the formation of “silent synapses” characterized by an altered receptor ratio. Which of the following best describes this synaptic adaptation? B. Decreased AMPA/NMDA receptor ratio at glutamatergic synapses Paper for next week: Takeda, Tomoya, Hidehiro Umehara, Yui Matsumoto, Tomohiro Yoshida, Masahito Nakataki, and Shusuke Numata. “Schizophrenia and Cognitive Dysfunction.” *Journal of Medical Investigation* 71 (August 2024): 205–209. Rotations  2.0 is copyrighted. But you can use any content from the podcast for non-commercial purposes under Creative Commons….BUT, BUT, BUT, you must cite Rotations 2.0 and Todd Fredricks DO MSS as the source of the material AND AND AND you cannot alter or edit the content in any manner without expressed permission of Todd Fredricks DO MSS. Rotations 2.0 is made possible by the generous understanding and accommodation of my beloved institution, Ohio University. The comments and ideas expressed on Rotations 2.0 are that of the content creators alone and may not reflect official policy or the opinion of the Ohio University, the State of Ohio, or the US Government or any other state, person or governmental agency. Listeners interested in specifics from the paper authors should contact them directly through their respective institutions. Any therapeutic ideas discussed should not be taken as any kind of medical advice or recommendations by the content creators and the content creators are not offering medical advice but discussing topics from an academic perspective. Listeners seeking advice about any medical care or decision-making should consult their own physician or medical provider and the content creators of Rotations 2.0 assume no liability for any listener's care or decision-making stemming from the topics discussed on Rotations 2.0.