parkinsonian syndrome

And I knew what could be happening, what could be coming in the future.

Some people call it Parkinson's almost like an accelerated aging process because a lot of elderly people develop Parkinsonian-like syndromes with tremor and weakness and balance problems.

Parkinson's has sometimes been thought of as being an accelerated form of aging, but it's really not.

It's more specific to other parts of the brain.

It's approved for severe orthostatic hypotension.

I have a few patients on that, but it's more this kind of shy Drager-type syndrome where you have these fairly dramatic drops in blood pressure, often in older people that have a Parkinsonian-type disease, even if they're not officially diagnosed with Parkinson's syndrome.

Yeah, and all of those are helpful to some degree from the literature that I reviewed.

The effectiveness in those drugs still results, however, in about 60% to 70% of patients that develop POTS still have to claim some form of disability.

or 80 if you want more contemporary things if you look at the average age of the first 10 u.s presidents when they died you know george washington john adams it was 78 john adams age 90s writing letters to thomas jefferson age 83 in 1826 and neither of them has parkinson's neither has alzheimer's disease none of the early presidents had either disease If you look at the average age of death for the last 10 U.S. presidents who died, it's also 78.

And, you know, numerous of these individuals have had neurological diseases like Ronald Reagan with Alzheimer's and President George H.W. Bush with a Parkinsonian disorder.

If you want to look in the lab, you put a laboratory animal in the lab and you let it age.

It will never spontaneously develop Parkinson's disease.

Parkinson's disease is largely a man-made disease.

Yes, some of your listeners will notice that some people got Parkinson's disease or something like Parkinson's from influenza pandemic or sleeping sickness in 1918.

And if your people have seen the movie Awakenings, these are individuals who got a Parkinsonian disorder 1919, 1920. that got infection likely from influenza that got a pro-concerning disorder.

And Robin Williams in the movie plays Oliver Sacks, and he gives him a little bit of levodopa, which led to a temporary awakening for these individuals.

I think he was 16.

Um, and it had left him with Parkinsonisms.

I think it was a right-sided weakness, right or left-sided weakness, one-sided weakness.

Um, a lot, a lot of difficulty in terms of like cognitive abilities completely there.

that person would never come back.

Post-encephalitic Parkinsonism is the most common symptom of the chronic phase.

It leads to extreme stiffness in the upper body.

Patients are often rendered completely unable to move their arms.

Reports date back to 1934 when he was 45 years old.

However, some sources indicate that he may have had transient symptoms starting in 1923 at the age of 34.

This would be classed as young-onset Parkinsonism, and it would align with the 1920s epidemic of encephalitis lethargica.

His most well-known symptom was a tremor in his left hand.