461: Quad Strength and Hypertrophy Markers After ACLR

People still have long-term deficits after ACL reconstruction.

Does that surprise you, Meg?

No. No.

yeah neither neither does it surprise me uh so this study was trying to quantify whether these could be detected with hypertrophy signal pathways and we'll get into how they how they tested that uh as well as global strength deficits and by global i mean one rm uh single leg press testing and training.

So effectively, they took this group of 12 participants, very wide range post ACL injury, and they looked at muscle volume through MRI scans.

They took muscle biopsies before and after an exhaustive or relatively strenuous leg press exercise intervention.

And then they looked at the biopsy signal pathways for both the resting and the post exercise.

And effectively what they found were that there were still muscle volume deficits, specifically in the vastus lateralis and the rec fem, right? Those were the, it was kind of full volume.

Yeah.

Full volume of the quadriceps, specifically rec fem and vastus lateralis, not significantly of the other two quad muscles.

And the, there's no association with the leg press one RM strength difference.

nor any of the observable hypertrophy pathways.

So the main marker they were using was this mTORC1, rapamycin complex 1. which is a indicator for hypertrophy with repeated pathway activation and reduced mTORC1 results in atrophy and decreased protein synthesis.

So it's thought that this is a valid marker of hypertrophy.

Is that something that-

Yeah, I'm vibing with that.

All right.

We're

outside of our domain here.

Bear with us.

Yep.

So that was more or less that.

Thoughts on the title?

Too long.

Oh, my God.