Metformin!

Still the most commonly drug prescribed for people with diabetes (and the third most commonly prescribed drug in the US!) but what is it and what is it doing? Kelly and Erin talk through the very beginning of it's story to where we are now and everything in between. References: 1. LaMoia TE, Shulman GI. Cellular and Molecular Mechanisms of Metformin Action. *Endocr Rev.* 2021;42(1):77-96. doi:10.1210/endrev/bnaa023 2. American Diabetes Association Professional Practice Committee for Diabetes. 9. Pharmacologic Approaches to Glycemic Treatment: Standards of Care in Diabetes-2026. *Diabetes Care.* 2026;49(Suppl 1):S183-S215. doi:10.2337/dc26-S009 3. Pavlo Petakh, Kamyshna I, Kamyshnyi A. Effects of metformin on the gut microbiota: A systematic review. Mol Metab. 2023 Nov;77:101805. doi: 10.1016/j.molmet.2023.101805. Epub 2023 Sep 9. PMID: 37696355; PMCID: PMC10518565. 4. Bu Y, Peng M, Tang X, et al. Protective effects of metformin in various cardiovascular diseases: Clinical evidence and AMPK-dependent mechanisms. *J Cell Mol Med.* 2022;26(19):4886-4903. doi:10.1111/jcmm.17519 **LINKS**: Email us your questions here: [**glucoseriotpod@gmail.com**](mailto:glucoseriotpod@gmail.com) Find out more about Kelly at **www.sixnutritionanddiabetes.com** Find out more about Erin at **www.erinphillipsnutrition.com** **DISCLAIMER:** We are dietitians and diabetes educators but we are not YOUR dietitians and diabetes educators. The information provided in this podcast is not intended as individualized medical advice, nor is it a substitute for professional medical expertise or treatment. If you have a medical concern, go to your health care provider or seek other professional medical treatment.