Empagliflozin
MedicationWikipedia
41
MENTIONS
27
EPISODES
24
PODCASTS
Search complete. 41 mentions across 27 episodes found for "Empagliflozin".
Oct 30, 2026
Jack CushHOST
And they looked at patients who were treated with SGLT2 inhibitors.
Jack CushHOST
That includes drugs like Jardiance and the like.
Jack CushHOST
In this group, 70% were lupus patients, 25% scleroderma.
Jack CushHOST
SGLT2 inhibitor use was associated with significantly lower all-cause mortality and heart failure risk.
CassandraGUEST
Taking what? My
Meredith PoczkalskiHOST
Jardiance.
CassandraGUEST
And what does that do? So Jardiance helps your body flush sugar and helps heal your kidneys.
CassandraGUEST
Oh, okay.
CassandraGUEST
From the damage.
Chris PrimoGUEST
Yeah.
Chris PrimoGUEST
But I mean, the last one I would say is Jardiance.
Chris PrimoGUEST
It doesn't really lower blood pressure that much, but it's kidney protective and heart protective.
Chris PrimoGUEST
Yeah.
10 MINS LATER
Nyle NaygaHOST
the
Chris PrimoGUEST
club.
Chris PrimoGUEST
Yeah, Jardiance.
Chris PrimoGUEST
Jardiance is freaking amazing.
Ed DeleskyHOST
Like they were taking like up to around 40% of them were taking a GLP-1 or I'm just going off now.
Ed DeleskyHOST
like 40% of them were taking a GLP-1 and a very large percentage of them were taking an SGLT2 inhibitor like Jardiance.
Ed DeleskyHOST
And these are so commonly used now for diabetes and we can get really great control of people's diabetes without using insulin.
Ed DeleskyHOST
And both groups were just not using insulin whatsoever.
Jay CampbellGUEST
One of those two in a microdose is Epic, obviously therapeutic testosterone, you know, something to ameliorate, you know, insulin sensitivity.
Jay CampbellGUEST
So obviously a metformin or an SGL-2 inhibitor like a Jardiance or even both.
Jay CampbellGUEST
A lot of people are using both.
Jay CampbellGUEST
If you're not using any of those, you want to use like, What is it?
Jay CampbellGUEST
One of those two in a microdose is Epic, obviously therapeutic testosterone, you know, something to ameliorate, you know, insulin sensitivity.
Jay CampbellGUEST
So obviously a metformin or an SGL-2 inhibitor like a Jardiance or even both.
Jay CampbellGUEST
A lot of people are using both.
Jay CampbellGUEST
If you're not using any of those, you want to use like, What is it?
Jay CampbellGUEST
One of those two in a microdose is Epic, obviously therapeutic testosterone, you know, something to ameliorate, you know, insulin sensitivity.
Jay CampbellGUEST
So obviously a metformin or an SGL-2 inhibitor like a Jardiance or even both.
Jay CampbellGUEST
A lot of people are using both.
Jay CampbellGUEST
If you're not using any of those, you want to use like, What is it?
Stephanie CoxGUEST
We got lots of info on.
Stephanie CoxGUEST
So the newer drugs, which would include things like Jardiance or the GLP ones like Dilaglutide or Saxenda that are the funded ones that we use really commonly, as well as things like the sulfonylureas like Glipizide, they're ones that we don't know as much about.
Stephanie CoxGUEST
Generally, when we think about drugs and safety in pregnancy, we think about two things.
Stephanie CoxGUEST
We think, one, does it cause birth defects or structural changes in a baby? That's what we call teratogenicity.
David AhnGUEST
So SGLT2 inhibitors are another class of medications, kind of the 1B of medications right now.
David AhnGUEST
And they're pills, once-daily pills, and brand names are such as Jardiance, Farxiga, Invokana.
David AhnGUEST
And they're really effective medications as well.
David AhnGUEST
So they help your body pee out sugar through your kidneys, but the benefits are pretty impressive because they've been shown to help protect your kidneys and they've actually been shown to help reduce your incidence of heart attacks and strokes in certain populations, which is very impressive.
Neil SkolnikGUEST
It is truly dizzying, and it is both filled with excitement but also challenge.
Neil SkolnikGUEST
So if we go back to 2015, you say the last decade, that's, that's, that's Empa-Reg, right? It was announced, the Empa-Reg trial of the empagliflozin and the cardiovascular outcomes that we now just kind of almost take for granted, was announced for the first time in Stockholm in September of 2015.
Neil SkolnikGUEST
And the group of usually quiet, relatively staid, uh, endocrinologists actually stood up and started clapping, 'cause never before in the history of diabetes had a medicine been shown during the course of a little over three-year study to have a significant effect on cardiovascular outcomes, empagliflozin did.
Neil SkolnikGUEST
Shortly after, we saw the leader trial of liraglutide.
Neil SkolnikGUEST
That was the first GLP-1.
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