Alzheimer’s Breakthrough with Dr. Josh Helman, MD
Aug 13, 2026 · 49 min · 11 segments
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Josh HelmanHost
You already mentioned several different potential causes of Alzheimer's and other types of dementia.

If you had to come up with a long list of potential different causes, and I know we don't have all the time in the world, but what would you say are some of the most important ones that would come to mind?
So I think about infections and infections that can cross the blood brain barrier specifically.
I've seen in my clinical practice a lot of cognitive decline in people who have tick-borne disease, mold issues.
So typically I'm seeing Lyme and co-infections like Bartonella, Babesia, or Lichia.
I'm seeing at the same time mold issues they have an allergy to mold spores or they have an allergy to mycotoxins or they have a high mycotoxin load for our audience the mycotoxins are the toxins that molds create i'm seeing high viral loads maybe epsom bar virus or cytomegalovirus hhv6 very very common in these patients so Many, many low-grade infections at the same time.
I'm also seeing a high environmental toxin load, high heavy metals, glyphosate, microplastics, things like that.
And now I know that the combination of these two things, infections... a multitude of them, and toxins, many of them together, cause immune dysregulation.
I would call the dementia and the brain fog, even Alzheimer's, a secondary illness to illnesses like this.
The sinuses, which is what I wanted to talk about today, the infections in the jaw, infections in the butt, all can cross the blood-brain barrier.

And one of the things that I've noticed with my patient population is we talk about the blood-brain barrier, but by the time I see patients who have brain fog and dementia, often the blood-brain barrier is no longer intact.

You already mentioned several different potential causes of Alzheimer's and other types of dementia.

If you had to come up with a long list of potential different causes, and I know we don't have all the time in the world, but what would you say are some of the most important ones that would come to mind?
So I think about infections and infections that can cross the blood brain barrier specifically.
I've seen in my clinical practice a lot of cognitive decline in people who have tick-borne disease, mold issues.
So typically I'm seeing Lyme and co-infections like Bartonella, Babesia, or Lichia.
I'm seeing at the same time mold issues they have an allergy to mold spores or they have an allergy to mycotoxins or they have a high mycotoxin load for our audience the mycotoxins are the toxins that molds create i'm seeing high viral loads maybe epsom bar virus or cytomegalovirus hhv6 very very common in these patients so Many, many low-grade infections at the same time.
I'm also seeing a high environmental toxin load, high heavy metals, glyphosate, microplastics, things like that.
And now I know that the combination of these two things, infections... a multitude of them, and toxins, many of them together, cause immune dysregulation.
I would call the dementia and the brain fog, even Alzheimer's, a secondary illness to illnesses like this.
The sinuses, which is what I wanted to talk about today, the infections in the jaw, infections in the butt, all can cross the blood-brain barrier.

And one of the things that I've noticed with my patient population is we talk about the blood-brain barrier, but by the time I see patients who have brain fog and dementia, often the blood-brain barrier is no longer intact.
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