Oct 5, 2026 · 17 min · 9 segments
We are providing 2026 update for our breast cancer episodes, today we cover an introduction on breast cancer screening, prevention.
You cannot avoid the pink that is everywhere.
And breast cancer affects one in eight women, which is why, unfortunately, it's such a We will all be affected by this by some women in our life, if not ourselves.
And so Karine, to start us off, what are risk factors for breast cancer?
So most breast cancers are sporadic, about 80%.
10 to 20% are familial, but we need to talk about the genetic predispositions that can raise the risk of breast cancer.
as well as CDH1, which increases the risk of both lobular breast cancer and diffuse gastric cancer.
And for BRCA2, the risk of contralateral breast cancer is 25%, and the risk of ovarian cancer is 13% to 29%.
And then the non-genetic risk factors are also important.
So thoracic radiation between the age of 10 to 30, lobular carcinoma in situ, which we'll talk more about in this episode, dense breast tissue, older age, early menarche, late menopause.
So basically anything that leads to prolonged estrogen.
the absence of breastfeeding or nolliparous status, the number of first-degree relatives with breast cancer, alcohol, current smoking, obesity, as well as menopausal hormone therapy.
Things that have not at this point in time been shown to increase the risk include caffeine, thankfully, IV fluids, cosmetic breast implants, hair dyes, and deodorants.
So
those are some of the few to think about.
Yes.
Absolutely.
I think those are some hot buzzwords that are out there, but not shown to increase the risks.
And so we definitely need to know criteria for when a woman should have genetic risk evaluation.
Karine, what are those times?
So you need to offer BRCA1 and 2 testing to any patient with a personal history of breast cancer under the age of 65, as well as patients over the age of 65 based on their family history, or if they're eligible for PARP inhibitors.
And for anyone with high penetrance panel testing, so those are the ones we just talked about, in addition to BRCA, PALB2, P10, and others, you need to think about testing under the age of 50, as well as anybody with triple negative breast cancer of any age, male breast cancer, multiple primaries, lobular cancer with a personal history of gastric cancer, as well as any qualifying family history, including history of ovarian, pancreatic, or prostate cancer.
Although some experts advocate universal testing of all breast cancer patients as far as genetic testing.
You cannot avoid the pink that is everywhere.
And breast cancer affects one in eight women, which is why, unfortunately, it's such a We will all be affected by this by some women in our life, if not ourselves.
And so Karine, to start us off, what are risk factors for breast cancer?
So most breast cancers are sporadic, about 80%.
10 to 20% are familial, but we need to talk about the genetic predispositions that can raise the risk of breast cancer.
as well as CDH1, which increases the risk of both lobular breast cancer and diffuse gastric cancer.
And for BRCA2, the risk of contralateral breast cancer is 25%, and the risk of ovarian cancer is 13% to 29%.
And then the non-genetic risk factors are also important.
So thoracic radiation between the age of 10 to 30, lobular carcinoma in situ, which we'll talk more about in this episode, dense breast tissue, older age, early menarche, late menopause.
So basically anything that leads to prolonged estrogen.
the absence of breastfeeding or nolliparous status, the number of first-degree relatives with breast cancer, alcohol, current smoking, obesity, as well as menopausal hormone therapy.
Things that have not at this point in time been shown to increase the risk include caffeine, thankfully, IV fluids, cosmetic breast implants, hair dyes, and deodorants.
So
those are some of the few to think about.
Yes.
Absolutely.
I think those are some hot buzzwords that are out there, but not shown to increase the risks.
And so we definitely need to know criteria for when a woman should have genetic risk evaluation.
Karine, what are those times?
So you need to offer BRCA1 and 2 testing to any patient with a personal history of breast cancer under the age of 65, as well as patients over the age of 65 based on their family history, or if they're eligible for PARP inhibitors.
And for anyone with high penetrance panel testing, so those are the ones we just talked about, in addition to BRCA, PALB2, P10, and others, you need to think about testing under the age of 50, as well as anybody with triple negative breast cancer of any age, male breast cancer, multiple primaries, lobular cancer with a personal history of gastric cancer, as well as any qualifying family history, including history of ovarian, pancreatic, or prostate cancer.
Although some experts advocate universal testing of all breast cancer patients as far as genetic testing.
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