Jun 1, 2026 · 1 hr 9 min · 14 segments
TWiN explains the finding that vaginal microbiota transfer ameliorates cesarean-associated neurodevelopmental deficits in mice via synthesis of a sphingosine derivative on neonatal skin. .Hosts…
Vincent RacanielloHost
Vivianne MorrisonHost
Tim CheungHost
I would like to say, I mean, I, I was talking to Vincent earlier, right before the show, um, it's hard for me to stay neutral on this paper, uh, because I was delivered, uh, via C-section, and I do wonder whether the, in different countries, there are different propensity for C-section versus, like, natural vaginal birth, and whether that has any consequences on people.
Uh, the two first, co-first authors are Hao Liu and Huiling Zhang, and the corresponding author is Rihua Shi.
Uh, but we're both functioning normally, as you can see, or maybe you think we're not functioning normally because we're very different.
So why is this an issue? Well, many studies have linked babies born by C-section to neurodevelopmental disorders.
So, uh, anyone thinking of having a baby, just think twice about having...
I mean, there's some reasons you have to have a C-section, but it's really, um, an interesting association.
And one of the hypotheses for this is that CS disrupts the transmission of microbes from the mother to the child.
And so, so normally you pass through the vagina, you acquire the vaginal microbiome on your skin, and it colonizes you, and that's good.
If you come out by C-section, you're now getting, uh, skin and environmentally derived bacteria onto you, and that actually delays your gut colonization, and it promotes dysbiosis, which means wrong kinds of, uh, bacteria.
So you take ma- maternal vaginal secretions, which you can collect, and you apply them immediately after C-section to restore this, uh, early, uh, gut microbiota exposure, right? So there's a picture in this paper where they take...
So they'll swab the, the vaginal secretions and then apply them to multiple sites on the newborn, uh, baby.
I would like to say, I mean, I, I was talking to Vincent earlier, right before the show, um, it's hard for me to stay neutral on this paper, uh, because I was delivered, uh, via C-section, and I do wonder whether the, in different countries, there are different propensity for C-section versus, like, natural vaginal birth, and whether that has any consequences on people.
Uh, the two first, co-first authors are Hao Liu and Huiling Zhang, and the corresponding author is Rihua Shi.
Uh, but we're both functioning normally, as you can see, or maybe you think we're not functioning normally because we're very different.
So why is this an issue? Well, many studies have linked babies born by C-section to neurodevelopmental disorders.
So, uh, anyone thinking of having a baby, just think twice about having...
I mean, there's some reasons you have to have a C-section, but it's really, um, an interesting association.
And one of the hypotheses for this is that CS disrupts the transmission of microbes from the mother to the child.
And so, so normally you pass through the vagina, you acquire the vaginal microbiome on your skin, and it colonizes you, and that's good.
If you come out by C-section, you're now getting, uh, skin and environmentally derived bacteria onto you, and that actually delays your gut colonization, and it promotes dysbiosis, which means wrong kinds of, uh, bacteria.
So you take ma- maternal vaginal secretions, which you can collect, and you apply them immediately after C-section to restore this, uh, early, uh, gut microbiota exposure, right? So there's a picture in this paper where they take...
So they'll swab the, the vaginal secretions and then apply them to multiple sites on the newborn, uh, baby.
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