Aug 23, 2026 · 1 hr 32 min · 13 segments
*Please note - due to graphs and example images, this podcast might be best consumed as the original video here:* https://youtu.be/lNYzhmQ1t0A This week on the…
Jessica DuffinHost
Rose MackenzieGuest
I think it's gonna be really difficult, um, to say because I think it's very individual, but do you see any patterns with patients using Mira around endo? And secondly, how can using Mira be helpful for understanding hormones and how they might be influencing someone's endo symptoms?

Well, so I like to explain first that, um, the hormone patterns are more of a result of the whole cascading event of endo.

First is some other hormone patterns are, I'll say, a little bit more predictable, meaning a patient who is, um, experiencing a certain phenotype of PCOS or now PMOS, I can predict a couple of different patterns that I might see, such as abnormally high LH or, um, difficulty producing estrogen and then they finally ovulate late typically, and then they finally get actually more estrogen after they ovulate than before.

But with endo, what's a lot trickier about that is it's, you have to think about the whole picture, right? You can have, um, severe inflammation, decreased blood flow to the right areas, and kind of this, like, downstream effect on the hormones versus something that's, mm, I'll say, disrupting the hormones at the root, like in PCOS.

So with that, unfortunately not, uh, everyone's experience of endo is the same.

And everyone's severity is different, and then everyone's hormones can act very differently as well.

And so I've heard it said, you know, a lot of patients with endo actually have estrogen deficiency, and, um, that can be true, but it's, um, the why, what is the why to that?

I think it's gonna be really difficult, um, to say because I think it's very individual, but do you see any patterns with patients using Mira around endo? And secondly, how can using Mira be helpful for understanding hormones and how they might be influencing someone's endo symptoms?

Well, so I like to explain first that, um, the hormone patterns are more of a result of the whole cascading event of endo.

First is some other hormone patterns are, I'll say, a little bit more predictable, meaning a patient who is, um, experiencing a certain phenotype of PCOS or now PMOS, I can predict a couple of different patterns that I might see, such as abnormally high LH or, um, difficulty producing estrogen and then they finally ovulate late typically, and then they finally get actually more estrogen after they ovulate than before.

But with endo, what's a lot trickier about that is it's, you have to think about the whole picture, right? You can have, um, severe inflammation, decreased blood flow to the right areas, and kind of this, like, downstream effect on the hormones versus something that's, mm, I'll say, disrupting the hormones at the root, like in PCOS.

So with that, unfortunately not, uh, everyone's experience of endo is the same.

And everyone's severity is different, and then everyone's hormones can act very differently as well.

And so I've heard it said, you know, a lot of patients with endo actually have estrogen deficiency, and, um, that can be true, but it's, um, the why, what is the why to that?
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