Episode 172 | Jeanne Parson is tired of juggling doctors and prescriptions

I want to start out today with some information for you.

It's about a new study reported in Sarcoidosis News.

Steve Bryson, PhD, is the author.

It says...

A study examining patients' blood and lymph nodes at the time of sarcoidosis diagnosis but before treatment found signs of inflammation but no detectable microorganisms.

And this challenges a long-held hypothesis that infectious microorganisms may be the cause of sarcoidosis.

Now, I'm going to pause here for a minute.

I don't think I have ever heard anybody express to me or on the podcast that microorganisms might be the cause of sarcoidosis.

I've never heard anybody really give anything with any authority in terms of what the cause might be other than maybe something that you inhaled.

Maybe that was a microorganism, but nobody was describing it as a microorganism being the cause of sarcoidosis.

But this is a hypothesis that's out there apparently.

And so this study looked at that.

And here's a quote from the study.

It says, our findings demonstrate that the inflammatory response detected in in the blood and lymph nodes of sarcoidosis patients at diagnosis can arise in the absence of active microbial presence within the affected lymph nodes, the researchers wrote.

If an active infection is not driving the disease, it may instead result from a dysregulated host immune response.

And they described the results in a study which was called, quote, Systemic and Local Lymph Node Inflammation at Disease Onset in Sarcoidosis Patients.

And it was published in ERG Open Research.

Now, to search for the microorganisms, the researchers performed comprehensive genetic analyses from preserved lymph node samples, and the analysis found no evidence of bacteria, fungi, viruses, or parasites in the sarcoidosis samples taken at the time of the diagnosis.

Microbacterium tuberculosis, long suspected as an infectious trigger of sarcoidosis, was also not detected.

The team is suggesting a dysregulated host immune response may drive the disease.

Another quote, our findings obtained at diagnosis and restricted to lymph nodes challenge the long-held paradigm that sarcoidosis is caused by a microorganism, the scientists wrote.

Instead, they support the hypothesis that the disease can arise from the host's own maladapted immune response.

All right, so that's the latest from Sarcoidosis News, trying to keep you updated on all the latest things going on as the world continues to try and figure out what is causing what is wrong with all of us.