Aug 10, 2026 · 1 hr 2 min · 12 segments
Send us Fan Mail Some supplements feed the tumor. Others block chemo. A drug designer breaks down what to avoid. 👉 Get your free guide…
Jay ChaplinHost
So with the topic for tonight, supplements that backfire, the real point to this is that the supplements that you take, the supplements that you can take are incredibly, incredibly context dependent.

And In all honesty, what works well for one person will probably fail miserably for another person.

There are really very few supplements or off-label drugs or vitamins that are truly across the board bad.

There is one, but in terms of across the board bad, There's really very, very few.

Vitamin B12 is the one that falls into that category, which sadly is incredibly common.


Almost everything else falls into these conditional buckets, the conditional buckets that people don't talk about, where in some cases the supplement is very, very helpful, and in other cases it's incredibly, incredibly bad.


So for instance, in the case of berberine, berberine is very, very useful, especially for controlling blood glucose.

And if you're having a low carb diet, whether that's a keto diet, carnivore, or extremely low carb, other variety, that's not going to be of additional help.

Now, there are certain cancers, particularly colorectal cancer, for which berberine in and of itself is directly useful.

But for the vast majority of other cancers, There's no real added benefit for berberine beyond the blood sugar control.

It's just unnecessary and potentially irritating to the lining of your intestines.

generally is useful it it has some utility the issue with egcg is not so much that it backfires but not taking enough and the amount of egcg that is necessary starts at about 1.6 grams and goes upward from there up to sometimes twice that 3.2 3.5 grams which again is a level that for some people can be irritating to the lining of the intestines EGCG is good in many cases.

So with the topic for tonight, supplements that backfire, the real point to this is that the supplements that you take, the supplements that you can take are incredibly, incredibly context dependent.

And In all honesty, what works well for one person will probably fail miserably for another person.

There are really very few supplements or off-label drugs or vitamins that are truly across the board bad.

There is one, but in terms of across the board bad, There's really very, very few.

Vitamin B12 is the one that falls into that category, which sadly is incredibly common.


Almost everything else falls into these conditional buckets, the conditional buckets that people don't talk about, where in some cases the supplement is very, very helpful, and in other cases it's incredibly, incredibly bad.


So for instance, in the case of berberine, berberine is very, very useful, especially for controlling blood glucose.

And if you're having a low carb diet, whether that's a keto diet, carnivore, or extremely low carb, other variety, that's not going to be of additional help.

Now, there are certain cancers, particularly colorectal cancer, for which berberine in and of itself is directly useful.

But for the vast majority of other cancers, There's no real added benefit for berberine beyond the blood sugar control.

It's just unnecessary and potentially irritating to the lining of your intestines.

generally is useful it it has some utility the issue with egcg is not so much that it backfires but not taking enough and the amount of egcg that is necessary starts at about 1.6 grams and goes upward from there up to sometimes twice that 3.2 3.5 grams which again is a level that for some people can be irritating to the lining of the intestines EGCG is good in many cases.
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