Glutamine

We went through all the amino acids.

Glutamine, number one.

Glutamate, which is in the same pathway, number two.

All the others are minimal.

ketogenic metabolic therapy in the absence of radiation.

You know, we try to sort of negotiate a little bit like try to delay radiation as much as possible.

So you would have surgery for a brain tumor and then you would institute ketogenic metabolic therapy, probably including Glutamine inhibitors drugs together with nutritional ketosis and we will try to delay radiation as much as possible So if the patient is doing well at three years out and we keep delaying radiation indefinitely, so it's never necessary basically I think that maybe that's an opening

Keep radiation in hand.

Also, interestingly, these cells love glutamine.

So they have a special, um, uh, appetite for glutamine.

Glutamine is an amino acid but is gluconeogenic.

So it can be converted into glucose, and it impairs the oxidative phosphorylation, which is your normal, uh, process to build, make energy and promote aerobic glycolysis, again, fueling the growth of the cells.

So Thomas Wimes is the, um, I think the leader, um, and he has been doing this work, uh, for last twenty years and predominantly in animal models.

Let's look at the next critical nutrient listed, glutamine.

The text boldly calls this the most important nutrient in stress overall.

Glutamine is a fascinating amino acid.

Under normal, non-stress conditions, it is considered a non-essential amino acid because your skeletal muscles synthesize enough of it to meet your daily needs.

But in stress.

And number 10.

10.

Glutamine rapidly becomes a conditionally essential amino acid during profound ICU stress.

This is so important when you've got cancer because the glucose, yes, is feeding the cancer cells.

Glutamine is also feeding cancer cells.

But it's the insulin that's telling the cancer cells to grow and divide.

It's the insulin that's actually stimulating the proliferation.

Uh, but, but applying this to cancer is cancer cells can s- they, actually, they struggle if they don't have the easy foods of glucose and glutamine.

Yeah.

Glutamine comes from protein.

Yeah.

So by going this, uh, at least a 16 hour, up to an 18 hour, I go at least 16-

But for her, adding thiamine with magnesium and potassium, because those are cofactors for absorption, She's turned a tremendous corner in what she's able to tolerate and doesn't make her sick to her stomach or trigger headaches anymore.

Glutamine is a really fascinating amino acid that does a lot of super, super cool things in the body, and it plays a particularly significant role in gut permeability.

So if you think about the phrase leaky gut, which some of you may have heard, you don't have to be a super scientist to kind of put together at least in a fuzzy way what that might imply, where you should have the tissues, the lining of your gut, some pretty tight junctions, but you can have what's called leaky.

leaky gut where things seep in and out more easily than they should.

Glutamine is fantastic for helping to heal the intestinal lining.

I typically recommend based on people's tolerances, a pretty high dose and then a powder form.

Simply because in order to get the amount that's super, super helpful, you need pretty high doses, which would be a gazillion pills that we're typically trying to avoid.

Let's look at some supplements and foods that can help with your gut.

Glutamine is obviously something that you want to look at.

Consider doing some glutamine supplements.

Go to the store and ask around.

Do some research.

Glutamine is a big one.

It's a big one I take a lot.

Mastic gum is great for killing organisms in the stomach.

Yeah.

The paper is titled Effects of Glutamine Supplementation on Atlantic Salmon Metabolic Performance at High Temperatures.

And the core question they tackled is just huge for climate resilience in our industry.

Right.

We are unpacking a fascinating 2024 study by Barbara Newick and her team.

Yeah.

The paper is titled Effects of Glutamine Supplementation on Atlantic Salmon Metabolic Performance at High Temperatures.

And the core question they tackled is just huge for climate resilience in our industry.