Dr. Terry Simpson - The Unfiltered MD
Jun 7, 2026 · 20 min · 9 segments
This week we talk about the Screw worm coming back to the US - and yes, it isn’t pretty. A viral update and what virus I am worried about in the world cup, as well as some good news about pancreatic…
But osteoarthritis, it turns out, isn't just mechanical, it is also inflammatory.
Fat tissue produces inflammatory signals that affect joints, blood vessels, liver, pancreas, nearly every organ system you can think of.
So when you start reducing, when you have anti-inflammatory agents like GLP-1s, and when obesity improves, inflammation improves.
The one thing that struck me about this study was that for years we told people with osteoarthritis to stay off the joint, to swim, to ride a bicycle, avoid walking too much.
Surprisingly, we found that people who continued walking kept their knees longer than people who didn't.
Muscles support joints, balance improves, strength improves, and perhaps most importantly, exercise itself has a certain anti-inflammatory component.
So we now know that regular physical activity improves insulin sensitivity, lowers inflammatory markers, improves vascular function, and changes metabolic signaling throughout the body.
That doesn't mean it wants to spend the rest of its life sitting in a recliner.
Science just has this wonderful way of humbling physicians, and every few years it taps us on the shoulder and says, "Remember that thing that you were absolutely certain about? Let's talk about it." There was another GLP-1 study this week involving more than a hundred and eleven thousand women, that those women who were taking a GLP-1 medication had significantly lower risk of breast cancer, about thirty percent lower.
But osteoarthritis, it turns out, isn't just mechanical, it is also inflammatory.
Fat tissue produces inflammatory signals that affect joints, blood vessels, liver, pancreas, nearly every organ system you can think of.
So when you start reducing, when you have anti-inflammatory agents like GLP-1s, and when obesity improves, inflammation improves.
The one thing that struck me about this study was that for years we told people with osteoarthritis to stay off the joint, to swim, to ride a bicycle, avoid walking too much.
Surprisingly, we found that people who continued walking kept their knees longer than people who didn't.
Muscles support joints, balance improves, strength improves, and perhaps most importantly, exercise itself has a certain anti-inflammatory component.
So we now know that regular physical activity improves insulin sensitivity, lowers inflammatory markers, improves vascular function, and changes metabolic signaling throughout the body.
That doesn't mean it wants to spend the rest of its life sitting in a recliner.
Science just has this wonderful way of humbling physicians, and every few years it taps us on the shoulder and says, "Remember that thing that you were absolutely certain about? Let's talk about it." There was another GLP-1 study this week involving more than a hundred and eleven thousand women, that those women who were taking a GLP-1 medication had significantly lower risk of breast cancer, about thirty percent lower.
The rest of this transcript — segmented and speaker-labeled, so you land on the exact moment something was said
Search every transcript — by keyword, by phrase, or by meaning, across every show Radar indexes
Trends — what is surging across podcasts, measured against its own baseline
Alerts — when a name you follow appears in a newly indexed episode
No account is needed to search Radar.
