Alzheimer’s Breakthrough with Dr. Josh Helman, MD
Oct 1, 2026 · 48 min · 11 segments
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Josh HelmanHost
So, so things like getting enough sleep, exercising, eating a prudent diet, and, um, having connection with people.
And, uh, I know when I give talks about this, um, I s- I, I now show a slide as a picture of my mom because these are all the things your mom told you to do.
I mean, I, I think one relatively recent set of findings, um, or, or a whole body of research now, um, that is looking at how and why aging occurs in general.
Uh, and, and for folks who, you know, haven't already read it, you may enjoy reading David Sinclair's book, um, where he talks about aging.
Um, you know, um, I think that, um, you know, you know, David has begun to use himself as an experimental subject, um, which has both the pros, uh, I mean, the advantages of him being able to have exquisite control over that participant, that research subject is himself, so he can do whatever he wants to himself, um, and has a lot of control.
At the same time, the sample size, um, which is the other hallmark of good experiments, is though as bad as it can get.

So, so things like getting enough sleep, exercising, eating a prudent diet, and, um, having connection with people.
And, uh, I know when I give talks about this, um, I s- I, I now show a slide as a picture of my mom because these are all the things your mom told you to do.
I mean, I, I think one relatively recent set of findings, um, or, or a whole body of research now, um, that is looking at how and why aging occurs in general.
Uh, and, and for folks who, you know, haven't already read it, you may enjoy reading David Sinclair's book, um, where he talks about aging.
Um, you know, um, I think that, um, you know, you know, David has begun to use himself as an experimental subject, um, which has both the pros, uh, I mean, the advantages of him being able to have exquisite control over that participant, that research subject is himself, so he can do whatever he wants to himself, um, and has a lot of control.
At the same time, the sample size, um, which is the other hallmark of good experiments, is though as bad as it can get.
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