L
Lance Baumgard
American physiologist
2
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Sep 24, 2026
Dr. Victoria Asselstine and Dr. Lance Baumgard: B Vitamins in Transition Cow Nutrition | Ep. 154
5:48
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6:09
6:25
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6:47

Victoria AsselstineGUEST
So how do you think there's a way we could look a little bit further into that? Is it measuring different things? Is it different nutritional supplementation? What are your thoughts on that?

Lance BaumgardGUEST
I wanted to touch briefly on some key variables you mentioned, NIFAs, ketones, and calcium.

Lance BaumgardGUEST
Because for a long time, our industry has assumed that high NIFAs and ketones and subclinical hypocalcemia are causing disease or they're causing problems in some type of productivity metric.

Lance BaumgardGUEST
And we think that, of course, because... for at least 60 years, we've been correlating our finding the relationship between the changes in those with negative outcomes.

Lance BaumgardGUEST
And that correlation has never really been very high to begin with and oftentimes inconsistent.

Lance BaumgardGUEST
So that's what led us to essentially start questioning whether or not the changes in these are something that we should be trying to actively intervene with.
Journal Club - Integrating Our Understanding of Stress Physiology
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Lance BaumgardGUEST
And it turns out one of the immune cells that resides in different types of epithelia, including your skin, and your lungs, and your gut, is called a mast cell.

Lance BaumgardGUEST
And, uh, w- one of the hormones of that HPA axis is called corticotropin releasing factor which binds to the mast cell, and it causes the mast cell to essentially vomit its contents.

Lance BaumgardGUEST
And for reasons that I think are yet, yet still to be determined, that, those signals that are inside the mast cell do two things.

Lance BaumgardGUEST
One, uh, they cause the GI tract to become hyperpermeable or to become leaky, and two, they cause goblet cells to make less mucus.
23 MINS LATER
