The Fellow on Call: The Heme/Onc Podcast
Sep 16, 2026 · 26 min · 16 segments
This week we kick off a two-part update to our CLL series, covering what has changed in frontline management since our original episodes. Using the case of a 68-year-old man with newly diagnosed…
So listeners, this may not be a shock to many of you, but Vivek and I were texting back and forth about some of the updates in CLL because he had seen a new patient.
And so I thought instead of just the two of us talking about it, why don't we just turn it into an episode I'm sure our listeners want to listen to.
Yeah, I think this is huge.
And everybody check out our original series for a little bit more detail on how we got here.
Today, we're really just going to focus on the updates in 2026 while covering some of the stuff we covered then.
I'm just going to dive right into it, Vivek.
Let's just set the stage, right? Let's say that we have...
A 68-year-old gentleman who presents to the emergency room really with several weeks of just not feeling well.
He reports lymphadenopathy, weight loss, fevers.
The ER checks some blood work, and he happens to have a white blood cell count of over 100,000, a hemoglobin of 8, and a platelet count of 60.
Last set of labs were from a year ago that were stone cold normal.
We get consulted as the hematology service and workup is ensued.
So I'm going to turn this over to you.
In 2026, since the last recording of our CLL episode, how are we thinking about approaching this patient in the first line setting for a newly
So listeners, this may not be a shock to many of you, but Vivek and I were texting back and forth about some of the updates in CLL because he had seen a new patient.
And so I thought instead of just the two of us talking about it, why don't we just turn it into an episode I'm sure our listeners want to listen to.
Yeah, I think this is huge.
And everybody check out our original series for a little bit more detail on how we got here.
Today, we're really just going to focus on the updates in 2026 while covering some of the stuff we covered then.
I'm just going to dive right into it, Vivek.
Let's just set the stage, right? Let's say that we have...
A 68-year-old gentleman who presents to the emergency room really with several weeks of just not feeling well.
He reports lymphadenopathy, weight loss, fevers.
The ER checks some blood work, and he happens to have a white blood cell count of over 100,000, a hemoglobin of 8, and a platelet count of 60.
Last set of labs were from a year ago that were stone cold normal.
We get consulted as the hematology service and workup is ensued.
So I'm going to turn this over to you.
In 2026, since the last recording of our CLL episode, how are we thinking about approaching this patient in the first line setting for a newly
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