Aug 31, 2026 · 20 min · 7 segments
On this episode of *Scrubcast*, Dr. Alma Cepika, assistant professor in the Division of General Surgery and chief of its new Surgical Sciences Section, explains how regulatory T cells help prevent the…
I try to make our episodes inclusive for all listeners, particularly when we tackle a new field in basic science.
So their original purpose is to prevent our immune system from attacking things it shouldn't attack.
which classifies them as helper T cells, as opposed to CD8 T cells that kill target cells, such as cells that are infected or tumor cells.
And the main difference between the CD4 Tregs and TR1 cells is where they come from.
They carry a protein, which is a transcription factor called FOXP3, and they are a distinct lineage of T cells that is, once they exit the thymus in the peripheral blood and start circulating around the body.
2025 Nobel Prize in Physiology and Medicine was actually awarded for the discovery of these cells.
On the other hand, TR1 cells have a very similar functional role and they act in a similar way.
I try to make our episodes inclusive for all listeners, particularly when we tackle a new field in basic science.
So their original purpose is to prevent our immune system from attacking things it shouldn't attack.
which classifies them as helper T cells, as opposed to CD8 T cells that kill target cells, such as cells that are infected or tumor cells.
And the main difference between the CD4 Tregs and TR1 cells is where they come from.
They carry a protein, which is a transcription factor called FOXP3, and they are a distinct lineage of T cells that is, once they exit the thymus in the peripheral blood and start circulating around the body.
2025 Nobel Prize in Physiology and Medicine was actually awarded for the discovery of these cells.
On the other hand, TR1 cells have a very similar functional role and they act in a similar way.
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