Jun 18, 2026 · 25 min · 10 segments
Epidemiology is the study of how and why diseases affect different groups of people, and what the science increasingly shows is that preventing disease and preserving health are deeply connected. In…
Immaculata De VivoGuest
Neha PathakHost
So when we talk about modifiable risk factors, we're talking about things individuals can actually change to influence their risk.
For endometrial cancer, the most important ones are obesity, physical inactivity, and hormonal factors, particularly prolonged exposure to estrogens without progesterones, 'cause this disease is defined by long-term exposure to estrogens, unopposed, as we say, by progesterone.
And we estimate that about 70 to 80% of endometrial cancers are linked to excess body weight.
So this is one of the cancers where lifestyle truly plays a central role.
And I wanna also bring up, if I may, some misconceptions about endometrial cancer, 'cause this is really important.
This came out of a focus group that we did many years ago with women who had endometrial cancer.
And because cervical cancer is associated with HPV, there can be stigma or shame attached to it, and unfortunately, that confusion can sometimes lead women to dismiss symptoms or delay seeking care.
So awareness is critical, especially recognizing that abnormal uterine bleeding is not something to ignore.
So I'd love to then dig into something that you talk a lot about in the book, which is stress.
So when we talk about modifiable risk factors, we're talking about things individuals can actually change to influence their risk.
For endometrial cancer, the most important ones are obesity, physical inactivity, and hormonal factors, particularly prolonged exposure to estrogens without progesterones, 'cause this disease is defined by long-term exposure to estrogens, unopposed, as we say, by progesterone.
And we estimate that about 70 to 80% of endometrial cancers are linked to excess body weight.
So this is one of the cancers where lifestyle truly plays a central role.
And I wanna also bring up, if I may, some misconceptions about endometrial cancer, 'cause this is really important.
This came out of a focus group that we did many years ago with women who had endometrial cancer.
And because cervical cancer is associated with HPV, there can be stigma or shame attached to it, and unfortunately, that confusion can sometimes lead women to dismiss symptoms or delay seeking care.
So awareness is critical, especially recognizing that abnormal uterine bleeding is not something to ignore.
So I'd love to then dig into something that you talk a lot about in the book, which is stress.
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