Sep 6, 2026 · 30 min · 10 segments
Listen to Professor Vanessa Murphy talk with Ian Woolf about asthma, its treatment and prevention. News of a drug to prevent inflammaging - the inflammatory disease of old age. Produced and hosted…
No diet for longer life? Researchers at Yale School of Medicine, drawing on blood samples from the CALERIE trial sponsored by the US National Institute on Aging, found that when restricting calorie intake causes animals and people to live longer, it's because a particular protein has been expressed.
This means we could get the benefit of eating a diet with higher nutrition but lower calories without actually changing what we eat and without harming our health.
In the decades since the 1930s, we've found the same result over and over in yeast, worms, flies, mice, and rats.
Reduced calorie intake without causing malnutrition and something in the biology of aging slows down.
It's very hard to replicate in humans, but all longevity researchers are extremely thin.
In that trial, 220 healthy adults were enrolled, and half of them were asked to cut their daily calorie intake by 25% for two years, while maintaining nutritional adequacy.
The calorie-restricted participants showed improvements in metabolic health, reduced inflammation, improved immune function, and biological aging markers that moved in the direction of slower aging.
Women researchers who persisted in this sort of diet have found that they stopped menstruating.
Low-calorie intake suppresses the hypothalamus, reducing the release of reproductive hormones.
Without those hormone signals, estrogen and progesterone levels drop, stopping ovulation and leading to missed periods.
Prolonged energy deficits lower your basal metabolic rate and disrupt thyroid function.
This leads to loss of lean muscle mass, aerobic capacity, and occasionally brief episodes of anemia.
One protein stood out above all the others, complement component 3, abbreviated as C3.
Complement component 3 is a central hub of the complement system, an ancient branch of the innate immune system that's been conserved across virtually all multicellular life.
Its primary function is to tag pathogens and damage cells for destruction by other immune components.
It is one of the most abundant proteins in human blood, present at concentrations several times higher than most other immune proteins.
Complement component 3 and the complement system also play a major role in driving inflammation.
The chronic, low-grade inflammatory state that accumulates with age and that underlies the biology of virtually every major age-related disease, from cardiovascular disease, type 2 diabetes, neurodegeneration to cancer.
In the calorie restricted calorie participants, complement component three levels dropped substantially compared to the control group.
No diet for longer life? Researchers at Yale School of Medicine, drawing on blood samples from the CALERIE trial sponsored by the US National Institute on Aging, found that when restricting calorie intake causes animals and people to live longer, it's because a particular protein has been expressed.
This means we could get the benefit of eating a diet with higher nutrition but lower calories without actually changing what we eat and without harming our health.
In the decades since the 1930s, we've found the same result over and over in yeast, worms, flies, mice, and rats.
Reduced calorie intake without causing malnutrition and something in the biology of aging slows down.
It's very hard to replicate in humans, but all longevity researchers are extremely thin.
In that trial, 220 healthy adults were enrolled, and half of them were asked to cut their daily calorie intake by 25% for two years, while maintaining nutritional adequacy.
The calorie-restricted participants showed improvements in metabolic health, reduced inflammation, improved immune function, and biological aging markers that moved in the direction of slower aging.
Women researchers who persisted in this sort of diet have found that they stopped menstruating.
Low-calorie intake suppresses the hypothalamus, reducing the release of reproductive hormones.
Without those hormone signals, estrogen and progesterone levels drop, stopping ovulation and leading to missed periods.
Prolonged energy deficits lower your basal metabolic rate and disrupt thyroid function.
This leads to loss of lean muscle mass, aerobic capacity, and occasionally brief episodes of anemia.
One protein stood out above all the others, complement component 3, abbreviated as C3.
Complement component 3 is a central hub of the complement system, an ancient branch of the innate immune system that's been conserved across virtually all multicellular life.
Its primary function is to tag pathogens and damage cells for destruction by other immune components.
It is one of the most abundant proteins in human blood, present at concentrations several times higher than most other immune proteins.
Complement component 3 and the complement system also play a major role in driving inflammation.
The chronic, low-grade inflammatory state that accumulates with age and that underlies the biology of virtually every major age-related disease, from cardiovascular disease, type 2 diabetes, neurodegeneration to cancer.
In the calorie restricted calorie participants, complement component three levels dropped substantially compared to the control group.
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