T2D & Bone Density, Microarchitecture, & Strength; Early Weight Loss, Glucose Tolerance, & Long-Term Mortality/CVD Risk; and more!

Welcome to the latest episode (October 2026) of *DOC Updates*, where every month Neil Skolnik, MD and John Russell, MD review the most important articles on diabetes, obesity, and cardiometabolic disease. **This month on *DOC Updates*:** Zoungas et al; Atorvastatin, Cardiovascular Events, and Disability-free Survival in Older Adults. *New England Journal of Medicine,* 28 August 2026; doi.org/10.1056/NEJMoa2607314 Novartis announces Lp(a)HORIZON Phase III topline results for pelacarsen in patients with elevated Lp(a) and established cardiovascular disease (CVD), press release N. Kruger, et al; Tirzepatide and the risk of atherosclerotic cardiovascular events: population based cohort study. *BMJ* 2026; 394 doi.org/10.1136/bmj-2026-100011 Dufour, et al; Type 2 Diabetes and Longitudinal Changes in Cortical and Trabecular Bone Density, Microarchitecture, and Strength: The Framingham Study. *Diabetes Care* 2026; dc260846. doi.org/10.2337/dc26-0846 He, et al; Early Weight Loss in Impaired Glucose Tolerance Is Associated With Reduced Long-term Mortality and Cardiovascular Risk: The Da Qing Diabetes Prevention Outcome Study. *Diabetes Care* 2026; dc260689. doi.org/10.2337/dc26-0689 Leavens ELS, Pebley K, Smith TT, et al; Nicotine E-Cigarettes for Cigarette Smoking Cessation: Recommendations to US-Based Clinicians. *JAMA*. 2026;336(9):783–790. doi.org/10.1001/jama.2026.13087 **Presented by:** Neil Skolnik, MD, Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health John J. Russell, MD, Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Chair-Department of Family Medicine, Abington Jefferson Health *DOC Updates* is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association's three science and medical journals—*Diabetes*, *Diabetes Care*, and *Diabetes, Obesity, and CardioMetabolic CARE*. Intended for practicing physicians and health care professionals, *DOC Updates* discusses how the latest research is relevant in clinical practice. For information about the American Diabetes Association's scholarly journals, visit diabetesjournals.org. For more about this podcast, click here.