Diabetes Care

What are they? We'll find out.

As a public health strategy to mitigate the harms of prolonged sitting, Then an article from Diabetes Care looking at progression to diabetes by adults with prediabetes who have used the National Diabetes Prevention Program.

Then an article from Diabetes Care on the genetic determinants of macronutrient intake and are they associated with specific food intake in youth.

followed by an article on sarcopenic obesity and the risk of incident type 2 diabetes, a prospective cohort study, also from Diabetes Care.

And finally, also from Diabetes Care, is an article on life quality course, cumulative BMI burden from childhood to adulthood and the risk of metabolic multimorbidity.

Let's jump in with our first article, which is evaluating movement breaks as a public health strategy to mitigate the harms of prolonged sitting.

This was an article done because we know That brief regular movement breaks had been proposed as a public health strategy to offset the known harms of prolonged sedentary behavior.

You take an hour for lunch every day.

The kidney is both a victim of glycation and the organ responsible for removing it, and that dual role is what makes the whole process self-reinforcing.

Rabeni and Thornalli, in a detailed review published in 2018 in the journal Kidney International, described exactly this concept.

AGE-free adducts, the small glycated fragments, rise sharply in plasma as filtration rate declines, and the dicarbonyl precursors that seed AGE formation build up in parallel.

Let me walk through where the damage actually lands.

The hyperglycemia and the glycation feed each other and the kidney sits at the very central intersection of both.

So let me turn to what the research actually shows because the strength of this story is that it is measurable in people, not just in a test tube, for example.

One of the more striking findings comes from work by Koska and colleagues that published their work in 2022 in the journal Diabetes Care.

Drawing on participants from two large clinical trials in type 2 diabetes, they showed that a panel of circulating AGEs predicted future loss of kidney function and the development of high-risk kidney, chronic kidney disease.

So let me give you the actual study.

In 2012, Diabetes Care, they compared a long unbroken sit against the same sit interrupted by two minutes of easy walking every 20 minutes.

Just two minutes of walking, count it, two.

That's a strolling pace.

So this is not theoretical.

This is something that was actually done, okay? And they actually published it in Diabetes Care and examined 132 C.

staphylococcus aureus strains isolated from diabetics with ulcers.

And researchers combined bacterial virulence, genotyping it with the C. elegans infection model, and they found something that was clinically fascinating.

Let me congratulate you on last week.

I saw you were awarded a Lifetime Achievement Award from the Association of Diabetes Care and Education Specialists.

That's a big deal.

Congratulations and welcome to our podcast.

Together, these studies expand and deepen our understanding while paving the way for better treatments, stronger prevention, and ultimately, cures for diabetes.

Unfortunately, this year's meeting was disrupted by attendees' activity on the first day of programming, when several ADA members were physically removed by local police for handing out copies of an editorial criticizing cuts to research grants and intervention programs that was published in the June 2026 issue of Diabetes Care, the association's official journal.

Aaron S. Kelly, Ph.D., a professor of pediatrics at the University of Minnesota who was among the researchers escorted out, told the New York Times that security staff asked the group to leave the Ernest N. Morial Convention Center and tried to take away the materials they were distributing.

When the researchers re-entered the convention center from another entrance, they were met by security staff and police officers.

A lot of groups don't do that, and the code is sitting somewhere three clicks down on the website, where people only see it when they register for the meeting, and you click through because they can complete your registration, but you know that doesn't mean you read it once you click through.

While the disruption at this event was unfortunate for all involved, especially attendees who traveled to present their own unrelated research, the group of diabetes researchers succeeded in their mission to draw attention to their editorial.

The ADA also created a new portal for members to submit public comments on the White House Office of Management and Budget's proposed Guidance for Federal Grantmaking, addressing the issue at the heart of the diabetes care editorial in a way that will help members elevate their voices.

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Hello, everyone, and welcome to the September 2026 episode of Diabetes Care On Air, a fun way to bring the research in diabetes care to life.

I'm Alice Cheng from the University of Toronto.

And I'm Mike Rickles from the University of Pennsylvania.

So there's a useful tidbit for anyone who has to work with me that I'm not trying to be rude, but it's just that when there's meetings that sort of go on and you know what I'm talking about, Mike, those just frustrate me to no end.

So I am all about getting stuff done.

Well, then without further ado, let's launch into the September 2026 episode of Diabetes Care On Air.

Alice and I will each conduct an interview with authors of feature articles as per usual, followed by a rapid exchange segment where we will each pick three articles of interest for discussion.

And to quote Amelia Earhart, the most effective way to do it is to do it.

I'm also gonna say that, okay? It is actually tied to your long-term health with real numbers behind it.

In 2019, uh, a study by Beck and his colleagues in the Journal of Diabetes Care found that t- every 10% you add to your time in range works out roughly to a 0.6% drop in your A1C, and when researchers went back and they reanalyzed that famous DCC trial, they found higher time in range linked to lower rates of complications that we genuinely worry about, like eye disease, kidney disease, small blood vessel stuff the doctors call microvascular complications.

So that flat, boring line after dinner is not just about a calm evening.

You're literally buying yourself protection, like years of it, a few minutes at a time.