The BMJ

So there's actually...

The paper is from the British Medical Journal, and there you can see the picture of the nail through the boot.

It's pretty great.

The second tale of nails.

What raises uric acid? Some very consistent culprits, sugar, especially fructose and sugary drinks.

A Harvard study by Hyland Choi and Gary Kurhan in the British Medical Journal in 2008 found men drinking two or more sugary soft drinks a day had about 85% higher risk of gout.

Alcohol, especially beer, shown by Choi and colleagues in The Lancet in 2004, red meat, organ meats, and some seafood, and dehydration, which reduces how much uric acid your kidneys clear, and is a well-known trigger for gout attacks.

If you carry the ABCG2 variant, your body has less spare capacity to clear uric acid, We can't say exactly how much more each trigger will affect you personally, which is why measuring your uric acid is so useful, and hydration is the easiest place to start, and it's free.

OK, the next one is women's hearts.

Now, I want to spend a couple of minutes on women specifically because women's heart risk gets underestimated.

by doctors and by women themselves we've already talked about menopause ldl and apolipoprotein b jump in about a year around the final period blood pressure tends to climb too and remember the abcg2 finding that uric acid gene matters more after menopause but there are clues much earlier in a woman's life that most people will never connect to their heart pregnancy is one of them so in 2007 Analysis in the British Medical Journal, Leanne Bellamy and colleagues pulled studies of women who had preeclampsia.

Later in life, they had about three to four times the risk of high blood pressure and roughly double the risk of heart disease.

What actually happened to people who underwent lobotomies? And the answer to that, well, it can only be a vague and nebulous one.

Put it this way, The closest thing that we have to a decent, well-sampled, self-reporting study from the patients themselves comes from 1956, when doctors A. Althorn and Elliot Slater published Prefrontal Leukotomy, Views of Patients and Their Relatives in the British Medical Journal.

As for what they said, their original group contained 118 patients not huge, admittedly, but we've got to work with what we've got, five of whom died as a direct result of the operation.

Then, after further losses and exclusions, 103 survivors who could actually be asked what they thought remained.

And, in fact, we've already met that something.

Chlorpromazine, the first effective antipsychotic, which reached psychiatric patients in France in 1952.

But it was in 1954 the British researchers Joel and Charmian Elks provided some of the first proper controlled evidence of what the drug could do, publishing their results in the British Medical Journal.

Their study involved 26 chronically overactive psychotic patients, each of whom received chlorpromazine and an inert placebo at different points across 22 weeks.

The year one loss was mostly measurement noise washed out, and they recognized that.

In 2009, a study by Bell in BMJ concluded that monitoring bone density in the first three years after starting bisphosphonate drugs was, quote, unnecessary and maybe misleading.

Why? It's not because the drug isn't doing anything.

It's because the change is going to be within the margin of error of the instrument that we're using to measure.

And and then we updated the protocol.

We published it in the BMJ, which is kind of like a bit of a

coup.

And and then we published the full RCT in BMC psychiatry last year yeah in 2025 so all of these things kind of like it's been like organic it's been like some of it is just pure serendipity you just end up working with somebody and then you pick up some ideas and you run with them and you end up doing a degree in that because it's something that you fancy you know or you end up working with a research team without looking for it they just invite you or you know but at the same time I was I was just being diagnosed and I thought oh wow I've got the opportunity to work in in research in ADHD and I'm just going through my diagnosis yes I'll do it yeah so it was all kind of like happening at the same time

Every time I've had a concussion, there's just a little change in your body that I think as an athlete I can feel.

A study earlier this year in the British Medical Journal found from a sample of NFL players who died between 2016 and 2021, a quarter had CTE.

In 2024, Boston University established a link showing the longer the career in amateur and professional hockey, the more likely an athlete was to have the disease.

In 2018, the NHL reached a settlement in a class action lawsuit that alleged the league knowingly concealed information regarding the risks of brain trauma while playing in the NHL, including an increased risk for CTE.

But most importantly, Mark, it is, in my view, this film uncovers literally how we have got this pandemic of chronic disease, both with Big Pharma and Big Food capturing, we've got medical knowledge.

We've got very credible experts, former editor of the BMJ.

We go into some dark stuff in there, just how many people have been killed by research fraud.

But we also give people hope with the lifestyle stuff.

And not only that, in one sense, like all specialists in various areas, like cancer specialists or heart specialists or neurologists, if things can be managed well at other levels of care, we obviously want to go.

In fact, I was associated with some very famous things in the British Medical Journal earlier on, that the more we do that, the more lives are saved, that suicides go down through better access to care.

So if you want to have a big impact, no. No.

Okay, so tell people, say, five questions.