CGMs & Non-Insulin-Treated T2D, Islet Autoantibody Screening & T1D, Semaglutide CVD Risk Reduction, and more!

Welcome to the latest episode (November 2026) of *DOC Updates*, where every month Neil Skolnik, MD and John Russell, MD review the most important articles on diabetes, obesity, and cardiometabolic disease. **This month on *DOC Updates*:** Oser, et al. Continuous Glucose Monitoring in Non–Insulin-Treated Type 2 Diabetes. *New England Journal of Medicine*. October 2026; doi.org/10.1056/NEJMoa2608571 Islet autoantibody screening identifies early-stage type 1 diabetes across Europe, Need-To-Know Institute press release Yang, et al. Sodium-Glucose Cotransporter 2 Inhibitor Use and Levels of Hemoglobin, Markers of Iron Metabolism, and Erythropoiesis. *JAMA*. Published online October 2026. doi.org/10.1001/jama.2026.19921 Jastreboff, et al. Retatrutide, a Triple Hormone Receptor Agonist, for Treatment of Obesity. *New England Journal of Medicine*. September, 2026. doi.org/10.1056/NEJMoa2604169 Bellido, et al. Retatrutide in adults with obesity and type 2 diabetes (TRIUMPH-2): a double-blind, parallel-group, randomised, placebo-controlled, phase 3 trial. *The Lancet*. Volume 408, Issue 10563. doi.org/10.1016/S0140-6736(26)01861-1 Colhoun, et al. Semaglutide and cardiovascular risk reduction: a mediation analysis of the SELECT trial. *European Heart Journal*. 2026; ehag524, doi.org/10.1093/eurheartj/ehag524 Garvey, et al. Petrelintide, a human amylin analogue for the treatment of obesity (ZUPREME 1): a randomised, double-blind, placebo-controlled, phase 2 trial. *The Lancet Diabetes & Endocrinology*, 2026; 14, 914-926. doi.org/10.1016/S2213-8587(26)00213-5 **Presented by:** Neil Skolnik, MD, Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health John J. Russell, MD, Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Chair-Department of Family Medicine, Abington Jefferson Health *DOC Updates* is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association's three science and medical journals—*Diabetes*, *Diabetes Care*, and *Diabetes, Obesity, and CardioMetabolic CARE*. Intended for practicing physicians and health care professionals, *DOC Updates* discusses how the latest research is relevant in clinical practice. For information about the American Diabetes Association's scholarly journals, visit diabetesjournals.org. For more about this podcast, click here.