Communicable E61: We will make you love PK/PD, part 3

[on-hold music] Hello and welcome back to Communicable, the podcast brought to you by CMI Communications, ESMID's open access journal covering infectious diseases and clinical microbiology.

My name is Angela Huttner, and I am the editor-in-chief of CMI Communications and an infectious diseases physician based at the Geneva University Hospital in Switzerland.

I'm joined by two co-hosts today.

The first is Amy Legge, assistant director of pharmacy and consultant pharmacist in infectious diseases and research in Brisbane, Australia, and editorial fellow at our sister journal CMI.

[laughs] Hi, great to be here.

So glad you're back.

And my second co-host is Réka Pai-Mangalar, ID physician from Melbourne whom you also know and love.

Hi, everyone.

Good to be here.

Thanks, Angela.

So today we're back with our third installment of the Love PK/PD series.

This time we will be unpacking MIPD or, for mere mortals, model-informed precision dosing, and we're delighted to have two expert guests with us.

The first is Amanda Gwe, associate professor of pediatrics at the University of Melbourne in Australia.

She's a general pediatrician, infectious diseases physician, and clinical pharmacologist at the Royal Children's Hospital in Naarm, Melbourne.

She's the head of the Clinical Pharmacology Unit at Royal Children's Hospital and leader of the Antimicrobials Group at Murdoch Children's Research Institute.

Amanda's research focuses on optimizing the dosing of anti-infective agents in children, an area of increasing importance given the emerging antimicrobial resistance.

And as part of her work, she's the creator of the beloved KidsCalc MIPD software.

She's also a fellow editor working for the Pediatric Infectious Diseases Journal and Journal of Antimicrobial Chemotherapy.

Amanda, welcome to Communicable.

Thanks so much for having me.

And I'm delighted to introduce our second guest, Sebastian Wicher, professor of clinical pharmacy at the University of Hamburg in Germany, where he leads the research group in clinical pharmacy at the Institute of Pharmacy.

His research is all about PK/PD and precision dosing of anti-infectives.

His group develops open access web-based software to foster MIPD, such as TDMx, which is available freely online.

He has served as president of the International Society of Anti-Infective Pharmacology, otherwise known as ISAPP, and as education officer and chairperson of ESMID's PK/PD Study Group.

And finally, he too is an editor at our potential competitor [laughs] the International Journal of Antimicrobial Agents.

Sebastian, it is great to have you here.

Thanks, Angela, for the kind introduction and thanks for having me today.

Before we jump in, I'll just say that both of our guests are developing software.

They're working hard on this.

But they have no financial conflicts of interest to declare.

Okay.

Leave it to you, Amy.