Thanks, Tina, for a fabulous editorial.

I won't spend a lot of time because I think I'd rather have discussions around everything.

I'll just really focus on the things which I think were also particularly important and that was around the primary outcome and the effect size.

So I thought I'd just go through how we landed on that.

So as you alluded to, we had done some earlier observational work around patients coming to the ED with septic shock.

And we found that in Australia and New Zealand, our mortality is less than 10%.

It's only around 8%.

And that goes on to then that if they'd already received this fluid resuscitation, does a litre difference in the first six hours or 24 hours really make a difference? Or do we really think that that would make a significant difference in terms of patient outcomes?