But Maggie, like how do you find the pathology to help clarify difficult cases in your practice?

Or does it? It definitely can.

My long answer is when it comes to muscle diseases in general, we break our disease states down into two categories, inherited or genetic, and acquired, like myositis.

So aside from inclusion body myositis, most all acquired myopathies will present with that limb girdle pattern of weakness.

And so any deviation from that would require further testing, thinking about inherited in the back of our minds.

And if a patient has that limb girdle pattern of weakness and we do a CK and it's very high, we can see that in muscular dystrophy just as much as we can see that in myositis.

And so in some of these cases, we do rely on the muscle biopsy to tell us the difference.

Maggie?