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Jonathan Rigby

CEO of Sernova Biotherapeutics and longtime type 1 diabetes patient, leading development of the Cell Pouch bio-hybrid organ as a functional T1D cure.

Oct 13, 2026

9:02
Can you describe that? What does that
9:03
mean? Sure.
9:05
So I'm happy to do that.
9:07
And I'm sure Will's response will enhance it further.
9:11
So the cell pouch is a small, very pliable surgical mesh.
9:17
that's formed into kind of, it's not as big as a credit card, it's very small, and it's very porous.
9:24
And what happens, the surgeon, he or she, will implant this little pouch beneath the skin and just above the muscles of the abdomen, and it's called the anterior rectus sheath.

6 MINS LATER

15:43
Going back to, you know, the merger and the technology at hand, the biohybrid organ, as you describe it, is anything like that being used for any other condition right now that we can point to and say, wow, look at that, they implanted this thing and everything grew around it and everybody's doing well? Or is this like a one of a kind for type 1?
2:42
So tell us a little bit about it.
2:44
Um, yeah, I can have a go at that one, Erin.
2:46
Thank you.
2:47
So look, uh, we, um, the, the folks at Sernova and the folks at Siraxis, we share, uh, the same mission, and the mission is to create what essentially would be a functional cure for people with type 1 diabetes.
3:04
Uh, Will and his team are highly motivated on this.
3:08
Uh, myself and my team are highly motivated on this, and, uh, I've been living with type 1 diabetes all my life, so this is a, a very personal thing for me.
3:17
And, uh, uh, in a nutshell, so, you know, Sernova, we've developed this implantable retrieval, retrievable, uh, medical device called the Cell Pouch, which can be put underneath the skin of the abdomen, and it can house islet cells, which are the cells that create insulin and other hormones to control, uh, blood glucose.

7 MINS LATER

10:07
And, uh, so we recognize that risk, and that's why we're taking, uh, multiple different, uh, strategies, uh, to be sure that, um, we-we're gonna succeed in our goal.
11:18
[laughs]
11:19
No, that's, that's, that's true.
11:20
I mean, yeah, the company's been around for a while, and has been developing, uh, what we call is, uh, the Cell Pouch.
11:28
And the Cell Pouch is a small implantable medical device made of a surgical mesh.
11:33
This goes beneath the skin of the abdomen and above the muscles of your abdomen, and we put islet cells into it.
11:40
So what we've been doing, we've been, uh, we finished a clinical trial, uh, but we used cadaveric, uh, islet cells.
11:48
So these are islets donated from, uh, a deceased person, unfortunately.

26 MINS LATER

37:38
Yeah.

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