Fran Ballamuth
Division Chief of Pediatric Emergency Medicine at Children's Hospital of Philadelphia; sepsis researcher and co-PI of the PROMPT BOLUS trial.
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Jul 22, 2026
Fran BallamuthGUEST
And I guess just to give a little bit of background in terms of biologic rationale.
Fran BallamuthGUEST
So I think, you know, the reason why people think that balanced fluids may be superior to saline for sepsis really has to do with chloride load.
Fran BallamuthGUEST
And there is strong evidence, both from kind of animal studies as well as humans, that if you get a lot of saline, it induces hyperchloremia.
Fran BallamuthGUEST
And that hyperchloremia may lead to kind of downstream kidney injury and then kind of downstream clinical effects from that.
17 MINS LATER
