David Baker
American biochemist
6
APPEARANCES
6
PODCASTS
012
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Sep 22, 2026
David Baker - Baker’s Blades
24:39

Jamie AppsHOST
I was like, yeah, this feels like it could have been on the History Channel or Netflix or one of the streaming services.
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24:51David BakerGUEST
So I had to run up there, get measurements of the sword, run back, build the sword, film it, film interview stuff.
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27:03Andy CoyneADVERTISER
You know, and showing that
David Baker, Swordmaker (185)
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31:08David BakerGUEST
But to clarify, in the prop world, you're going to make, say your, your average movie, so let's call it a low budget movie because you'll make multiples of whatever.
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31:25David BakerGUEST
You might have a secondary blade for that that's sharp if you need to do a, a shot where you're cutting something.
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31:33David BakerGUEST
You know, the special effects guys will probably, "Oh, we need the sharp too 'cause we're gonna cut a candle, cut a head of lettuce, cut whatever." Okay, great.
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31:40David BakerGUEST
Then you're going to have your aluminum swords, which are your, your fighting sword.
How execs from Ulta Beauty, Tarte and Beekman 1802 are implementing AI into workflows
23:08
23:25
23:35
23:46
26:56

David BakerGUEST
But I think where, where I'm starting to articulate this more, w- we have not articulated as, as, as loudly as I'm about to right now, but I feel like, uh, everyone's afraid that AI is coming for their jobs.

David BakerGUEST
I firmly do not believe that AI is coming for anyone at Beekman's job, but someone who knows how to a- use AI is gonna come for someone who doesn't know how to use AI's job.

David BakerGUEST
And, like, if you are still there, like y- if, if you hired a finance person and they were doing spreadsheets with pen and paper like they used to do in the '50s and '60s, you'd fire that person.

David BakerGUEST
And I think, like, we are getting to the level where we have incredible tools at our disposal, and someone choosing not to use them, that, that becomes a, a, a business risk.

Jenna Manula LinaresGUEST
They're gonna want an experience that is relevant, personalized, and fast, and I just think that's gonna be the nature of it.
Fail and Fail Big | David Baker | JP Dinnell Podcast 136
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53:03David BakerGUEST
Um, so Cast in Steel, uh, is something that, that's been going on for, um, a number of years.
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53:20David BakerGUEST
Anyway, um, and it's all about getting, uh, people in, in college, uh, to look at, um, material science, um, manufacturing, design on an industrial level.
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53:41David BakerGUEST
We've done, we, we did George Washington's swords last year before we did an African spear.
23 MINS LATER
Why building new proteins from scratch is our new superpower | David Baker
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7:45David BakerGUEST
So we began quite a few years ago to try to understand how the amino acid sequences of proteins determine their three-dimensional structures.
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7:56David BakerGUEST
And just as a little bit of background so everyone's on the same page, the genes in our genomes each encode a protein.
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8:05David BakerGUEST
And the way they encode that protein is by specifying the sequence of amino acids in the protein.
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8:11David BakerGUEST
And once that sequence is known, then that specifies what the three-dimensional structure is.
17 MINS LATER
25:32
How do we safeguard against misuse in a world where some people are, there are some bad actors and looking to-
Why building new proteins from scratch is our new superpower | David Baker
3:45
3:54
4:05
4:16
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3:42Whitney Pennington RodgersHOST
Can you talk a- about how exactly you did this?
David BakerGUEST
And in fact, there's been a very big, uh, uh, transition between 2019 when I gave the TED Talk and today.
David BakerGUEST
So we began quite a few years ago to try to understand how the amino acid sequences of proteins determine their three-dimensional structures.
David BakerGUEST
And just as a little bit of, of, of background for, um, so everyone's on the same page, the genes in our genomes each encode a protein.
David BakerGUEST
And the way they encode that protein is by specifying the sequence of amino acids in the protein.
19 MINS LATER
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22:54Whitney Pennington RodgersHOST
How do we safeguard against, um, misuse, uh, in a world where some people are, you know, there are some bad actors and looking to use things for-