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David Baker

David Baker

American biochemist

Sep 22, 2026

24:39
I was like, yeah, this feels like it could have been on the History Channel or Netflix or one of the streaming services.
24:45
Thank you.
24:46
And that's the goal.
24:47
And I'll tell Brittany, you said so.
24:49
Anyway, so the sword was there.
24:51
So I had to run up there, get measurements of the sword, run back, build the sword, film it, film interview stuff.
24:59
Brittany is writing all the interview things.
Andy CoyneADVERTISER
27:03
You know, and showing that
31:06
Okay.
31:08
But to clarify, in the prop world, you're going to make, say your, your average movie, so let's call it a low budget movie because you'll make multiples of whatever.
31:20
You're going to have one hero, right? That's a real thing.
31:24
That's a steel-bladed sword.
31:25
You might have a secondary blade for that that's sharp if you need to do a, a shot where you're cutting something.
31:33
You know, the special effects guys will probably, "Oh, we need the sharp too 'cause we're gonna cut a candle, cut a head of lettuce, cut whatever." Okay, great.
31:40
Then you're going to have your aluminum swords, which are your, your fighting sword.
34:44
So can you talk a little bit about those kinds? 'Cause you make everything.
23:08
Mm.
23:08
But I think where, where I'm starting to articulate this more, w- we have not articulated as, as, as loudly as I'm about to right now, but I feel like, uh, everyone's afraid that AI is coming for their jobs.
23:21
I mean, it's literally headlines everywhere.
23:25
I firmly do not believe that AI is coming for anyone at Beekman's job, but someone who knows how to a- use AI is gonna come for someone who doesn't know how to use AI's job.
23:35
And, like, if you are still there, like y- if, if you hired a finance person and they were doing spreadsheets with pen and paper like they used to do in the '50s and '60s, you'd fire that person.
23:46
And I think, like, we are getting to the level where we have incredible tools at our disposal, and someone choosing not to use them, that, that becomes a, a, a business risk.
26:56
They're gonna want an experience that is relevant, personalized, and fast, and I just think that's gonna be the nature of it.
27:03
Um, I'll, I'll, I'll go with my controversial one.
53:03
Okay.
53:03
Um, so Cast in Steel, uh, is something that, that's been going on for, um, a number of years.
53:10
Um, SFSA, uh, Steel Founders Association.
53:17
I, I get it wrong all the time.
53:20
Anyway, um, and it's all about getting, uh, people in, in college, uh, to look at, um, material science, um, manufacturing, design on an industrial level.
53:37
So these college teams work with industrial partners to cast something.
53:41
We've done, we, we did George Washington's swords last year before we did an African spear.

23 MINS LATER

77:02
Mm-hmm.
7:41
Can you talk a- about how exactly you did this?
7:44
Yes.
7:45
So we began quite a few years ago to try to understand how the amino acid sequences of proteins determine their three-dimensional structures.
7:56
And just as a little bit of background so everyone's on the same page, the genes in our genomes each encode a protein.
8:04
That's what they do.
8:05
And the way they encode that protein is by specifying the sequence of amino acids in the protein.
8:11
And once that sequence is known, then that specifies what the three-dimensional structure is.

17 MINS LATER

25:32
How do we safeguard against misuse in a world where some people are, there are some bad actors and looking to-
Whitney Pennington RodgersHOST
3:42
Can you talk a- about how exactly you did this?
3:45
Yes.
3:45
And in fact, there's been a very big, uh, uh, transition between 2019 when I gave the TED Talk and today.
3:54
So we began quite a few years ago to try to understand how the amino acid sequences of proteins determine their three-dimensional structures.
4:05
And just as a little bit of, of, of background for, um, so everyone's on the same page, the genes in our genomes each encode a protein.
4:14
That's what they do.
4:16
And the way they encode that protein is by specifying the sequence of amino acids in the protein.

19 MINS LATER

Whitney Pennington RodgersHOST
22:54
How do we safeguard against, um, misuse, uh, in a world where some people are, you know, there are some bad actors and looking to use things for-

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