[laughs]

That's a very important question, Ilaria, because the disease itself starts very differently for every patient.

This means that when I ...

If I think about the time I was in medical school, and I was taught in the rheumatology classes, systemic sclerosis starts with Raynaud phenomenon.

Raynaud phenomenon will be the first sign of the disease in 99% of the patients.

So this is where we have to act because this is the way the disease starts for most of the cases.

Then you move on with your studies.

Is there, Dr. Bruni, anything you would like to add before we finish?