Sep 29, 2026 · 15 min · 8 segments
Menopause changes more than your hormones. But could those changes also affect your heart? When women think about menopause, they often focus on hot flashes, disrupted sleep, mood changes, and weight…
Georgia NabHost
Chelsea NabHost
Don't eat fat, right? That was the old adage is fat causes cardiovascular disease.

And in our peri and postmenopausal, women and their cardiovascular risk factors, like a huge shift.

So as our hormones decline, especially estrogen, it has a big impact on our lipids and our cholesterol in a negative way.

And also as it declines, it affects the health of our blood vessels, the endothelial lining, the integrity of how our blood vessels function.

They can stiffen and harden and cause more stress on the heart and then get that buildup of plaque and cholesterol, which we want to avoid.

Nitric oxide is also affected by estrogen, right? So what's the impact there on nitric oxide? So it has a lot to do with estrogen helps to promote nitric oxide, right? So if we start losing our estrogen, then nitric oxide goes down.

The other thing is I will look at labs day in and day out, and I'll see total cholesterol might be sitting in the 190s, but those LDLs on my postmenopausal women might be sitting around 140, 150, and my female patients are worried.

What estrogen is doing on those LDLs is it's causing the receptors for those LDLs to not answer, to basically not hear.

And so those LDLs are going to sit in the blood longer because the receptors aren't there.

Don't eat fat, right? That was the old adage is fat causes cardiovascular disease.

And in our peri and postmenopausal, women and their cardiovascular risk factors, like a huge shift.

So as our hormones decline, especially estrogen, it has a big impact on our lipids and our cholesterol in a negative way.

And also as it declines, it affects the health of our blood vessels, the endothelial lining, the integrity of how our blood vessels function.

They can stiffen and harden and cause more stress on the heart and then get that buildup of plaque and cholesterol, which we want to avoid.

Nitric oxide is also affected by estrogen, right? So what's the impact there on nitric oxide? So it has a lot to do with estrogen helps to promote nitric oxide, right? So if we start losing our estrogen, then nitric oxide goes down.

The other thing is I will look at labs day in and day out, and I'll see total cholesterol might be sitting in the 190s, but those LDLs on my postmenopausal women might be sitting around 140, 150, and my female patients are worried.

What estrogen is doing on those LDLs is it's causing the receptors for those LDLs to not answer, to basically not hear.

And so those LDLs are going to sit in the blood longer because the receptors aren't there.
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