Sep 25, 2026 · 18 min · 8 segments
After an unsuccessful treatment 20 years ago, Bunting MacCauley is now celebrating a year free of Sickle Cell Disease. Learn how essential hospital Jefferson Health, in Philadelphia, is innovating in…
Bunting MacCauleyGuest
Osama GirgisGuest
James SwanHostSophie LanskronGuestBut in sickle cell disease, they've inherited two genes, one from mom and one from dad.
And when you have sickle cell disease, Your hemoglobin molecules stick together in your red cells and it changes the shape of your red cell, giving it that sickle form.
And that causes a lot of downstream problems, the major one being hemolysis or breakdown of those red cells.
But because of the breakdown of those red cells and the stiff red cells and increased reticulocyte count, those cells can get stuck in the microvasculature and cause significant amount of pain, which is the most common complication of the disease.
But in sickle cell disease, they've inherited two genes, one from mom and one from dad.
And when you have sickle cell disease, Your hemoglobin molecules stick together in your red cells and it changes the shape of your red cell, giving it that sickle form.
And that causes a lot of downstream problems, the major one being hemolysis or breakdown of those red cells.
But because of the breakdown of those red cells and the stiff red cells and increased reticulocyte count, those cells can get stuck in the microvasculature and cause significant amount of pain, which is the most common complication of the disease.
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