The Saliva Testing Gap in Hormone Therapy: Clinical Outcomes & Solutions

Send us Fan Mail In this episode, Dr. Mark Holthouse joins Dr. Jaclyn Smeaton and DUTCH founder Mark Newman to discuss a recent peer-reviewed publication from Precision Analytical, Inc. in *Frontiers* on hormone monitoring methods, including saliva testing, for testosterone hormone therapy.  Their discussion also covers:  - How saliva values spike when measuring transdermal testosterone or estradiol and the clinical impact - Dosing using saliva values and how it can cause overdosing or underdosing - The complexity of estradiol monitoring - The importance of relying on clinical evidence over established practice - Serum and urine testing’s clinical validity and how test values align with clinical outcomes **Show Notes**  Read our DUTCH Article on the Frontiers study, Mark Newman’s commentary, and the full study here.  Check out the resources mentioned in this episode:  - The topical progesterone cream study in *Fertility and Sterility* - The transdermal progesterone study from *Climacteric* - Good Energy mentioned by Dr. Holthouse - The study on the cardiovascular safety of TRT in the *New England Journal of Medicine* - The study on testosterone threshold levels and skeletal muscle strength Become a DUTCH Provider to gain access to comprehensive patient reports, peer-reviewed and validated research, and expert clinical support.